Chemical Property of 4-(Bromomethyl)benzoic acid
Chemical Property:
- Appearance/Colour:white to beige crystalline powder
- Vapor Pressure:7.45E-05mmHg at 25°C
- Melting Point:224-229 °C(lit.)
- Refractive Index:1.5500 (estimate)
- Boiling Point:328.8 °C at 760 mmHg
- PKA:4.10±0.10(Predicted)
- Flash Point:152.7 °C
- PSA：37.30000
- Density:1.635 g/cm3
- LogP:2.27970
- Storage Temp.:Store below +30°C.
- Water Solubility.:Soluble in water.
- XLogP3:2.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:213.96294
- Heavy Atom Count:11
- Complexity:139
- Purity/Quality:
-
99% *data from raw suppliers
4-(Bromomethyl)benzoic acid
*data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
C
- Hazard Codes:Xi,C
- Statements:
36/37/38
- Safety Statements:
26-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=CC=C1CBr)C(=O)O
-
Uses
4-(Bromomethyl)benzoic Acid is an intermediate in the synthesis of Eprosartan (E590100), a prototype of the imidazoleacrylic acid angiotensin II receptor antagonists used as an antihypertensive agent. 4-(Bromomethyl)benzoic acid acts as an intermediate in the synthesis of eprosartan, which is used as an antihypertensive agent. Further, it is used in the preparation of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), which is a second generation photosensitizer. In addition to this, it is used in the preparation of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids. 4-(Bromomethyl)benzoic acid was used in the chemical modification of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), second generation photosensitizer. It was also used in the synthesis of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.
