Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-

Base Information

• Chemical Name: Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-
• CAS No.: 16081-87-1
• Molecular Formula: C13H9N3O
• Molecular Weight: 223.234
• Mol file: 16081-87-1.mol

Synonyms:

Chemical Property of Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl-

There total 23 articles about Pyrido[2,3-d]pyrimidin-4(1H)-one, 2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-aminopyridine-3-carboxamide (13438-65-8) + toluene (108-88-3,15644-74-3,16713-13-6) → 2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one (16081-87-1)

Guidance literature:

With di-tert-butyl peroxide; iron(III) chloride hexahydrate; In dimethyl sulfoxide; at 110 ℃; for 65h;

DOI:10.1039/d0ob00866d

Reference yield: 92.0%

2-aminopyridine-3-carboxamide (13438-65-8) + benzylamine (100-46-9) → 2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one (16081-87-1)

Guidance literature:

With 4-phenylnaphthalene-1,2-dione; oxygen; trifluoroacetic acid; In dimethyl sulfoxide; at 120 ℃; for 24h;

DOI:10.1039/d0ra06820a

Reference yield: 80.0%

2-aminopyridine-3-carboxamide (13438-65-8) + triethoxymethylbenzene (1663-61-2) → 2-phenylpyrido<2,3-d>pyrimidin-4(3H)-one (16081-87-1)

Guidance literature:

With acetic acid; In ethanol; at 110 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.3390/molecules23112925

upstream raw materials:

2-benzoylaminonicotinamide

4-hydroxylamino-2-phenylpyrido<2,3-d>pyrimidine

2-amino-3-pyridinecarbonitrile

benzoyl chloride

Downstream raw materials:

4-chloro-2-phenylpyrido[2,3-d]pyrimidine

Refernces

• 1、 Jang, Yoonkyung,Lee, Seok Beom,Hong, Junhwa,Chun, Simin,Lee, Jeeyeon,Hong, Suckchang. "Synthesis of 2-aryl quinazolinones: Via iron-catalyzed cross-dehydrogenative coupling (CDC) between N-H and C-H bonds". supporting information. p. 5435 - 5441. Retrieved 2020/08/03.
• 2、 Sun, Jinwei,Tao, Tao,Xu, Dan,Cao, Hui,Kong, Qinggang,Wang, Xinyu,Liu, Yun,Zhao, Jianglin,Wang, Yi,Pan, Yi. "Metal-free oxidative cyclization of 2-amino-benzamides, 2-aminobenzenesulfonamide or 2-(aminomethyl)anilines with primary alcohols for the synthesis of quinazolinones and their analogues". . p. 2099 - 2102. Retrieved 2018/05/04.