3-Pyridinecarboxamide,2-amino-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxamide,2-amino-(9CI)
• CAS No.: 13438-65-8
• Molecular Formula: C6H7N3O
• Molecular Weight: 137.141
• Hs Code.: 29333990
• Mol file: 13438-65-8.mol

Synonyms:2-Aminonicotinamide;

Chemical Property of 3-Pyridinecarboxamide,2-amino-(9CI)

Chemical Property:

• Vapor Pressure: 0.000192mmHg at 25°C
• Melting Point: 194-200℃
• Refractive Index: 1.643
• Boiling Point: 328.2°C at 760mmHg
• PKA: 14.60±0.50(Predicted)
• Flash Point: 152.3°C
• PSA: 82.00000
• Density: 1.323g/cm³
• LogP: 1.04420
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-aminonicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxamide,2-amino-(9CI)

There total 13 articles about 3-Pyridinecarboxamide,2-amino-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-aminopyridin-3-carboxylic acid (5345-47-1) → 2-aminopyridine-3-carboxamide (13438-65-8)

Guidance literature:

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.3390/molecules25235693

Reference yield: 80.0%

2-aminopyridine-3-carboxylic acid ethyl ester (13362-26-0) → 2-aminopyridine-3-carboxamide (13438-65-8)

Guidance literature:

With ammonia; at 75 - 80 ℃; for 120h;

DOI:10.1021/jm00343a022

Reference yield: 50.0%

2-amino-3-pyridinecarbonitrile (24517-64-4) → 2-aminopyridine-3-carboxamide (13438-65-8)

Guidance literature:

With sulfuric acid; at 100 ℃; for 5h;

DOI:10.1021/acs.jmedchem.5b01528

upstream raw materials:

2-amino-3-pyridinecarbonitrile

methyl 2-aminonicotinate

nicotinamide

Malondialdehyde

Downstream raw materials:

2-[7-(4-morpholin-4-yl-phenyl)-[1,6]naphthyridin-5-ylamino]-nicotinamide

1-(3-carbamoyl-5-chlorobenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide

5-chloro-2-imino-1-(3-methylbenzyl)-1,2-dihydropyridine-3-carboxamide monohydrobromide

1-(3-carbamoylbenzyl)-5-chloro-2-imino-1,2-dihydropyridine-3-carboxamide monohydrobromide