tert-Butyl (2-methoxypyridin-3-yl)carbamate

Base Information

• Chemical Name: tert-Butyl (2-methoxypyridin-3-yl)carbamate
• CAS No.: 161117-83-5
• Molecular Formula: C11H16N2O3
• Molecular Weight: 224.26
• DSSTox Substance ID: DTXSID40453899
• Nikkaji Number: J662.157K
• Wikidata: Q82275184
• Mol file: 161117-83-5.mol

Synonyms:161117-83-5;tert-Butyl (2-methoxypyridin-3-yl)carbamate;TERT-BUTYL 2-METHOXYPYRIDIN-3-YLCARBAMATE;Tert-butyl N-(2-methoxypyridin-3-yl)carbamate;Carbamic acid, (2-methoxy-3-pyridinyl)-, 1,1-dimethylethyl ester;3-(Boc-amino)-2-methoxypyridine;SCHEMBL1723318;DTXSID40453899;SJYKVVNRRFYDSS-UHFFFAOYSA-N;MFCD11100821;AKOS014475955;CS-W000499;SB79949;AM807546;t-butyl (2-methoxypyridin-3-yl)carbamate;t-butyl N-(2-methoxy-3-pyridyl)carbamate;tert-Butyl(2-methoxypyridin-3-yl)carbamate;FT-0686184;3-(tert-Butoxycarbonylamino)-2-methoxypyridine;A851463;N-(2-Methoxypyridin-3-yl)carbamic acid tert-butyl ester;Carbamic acid, N-(2-methoxy-3-pyridinyl)-, 1,1-dimethylethyl ester

Chemical Property of tert-Butyl (2-methoxypyridin-3-yl)carbamate

Chemical Property:

• Boiling Point: 276.0±25.0 °C(Predicted)
• PKA: 12.31±0.70(Predicted)
• PSA: 60.45000
• Density: 1.146±0.06 g/cm3(Predicted)
• LogP: 2.51020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 224.11609238
• Heavy Atom Count: 16
• Complexity: 238

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 2-methoxypyridin-3-ylcarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=C(N=CC=C1)OC

Technology Process of tert-Butyl (2-methoxypyridin-3-yl)carbamate

There total 2 articles about tert-Butyl (2-methoxypyridin-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-amino-2-methoxypyridine (20265-38-7) + di-tert-butyl dicarbonate (24424-99-5) → 3-(N-tert-butoxycarbonylamino)-2-methoxypyridine (161117-83-5)

Guidance literature:

In 1,4-dioxane; for 24h; Reflux;

DOI:10.1016/j.bmcl.2008.10.034

Reference yield:

3-amino-2-methoxypyridine (20265-38-7) + tert-butyl chloroformate (24608-52-4) → 3-(N-tert-butoxycarbonylamino)-2-methoxypyridine (161117-83-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 91.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 3-(N-tert-butoxycarbonylamino)-2-methoxypyridine (161117-83-5) → 4-Formyl-2-methoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester (162709-22-0)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; hexane; 1.) -78 to -10 deg C, 2 h, 2.) -78 deg C to r.t., 3 h;

DOI:10.1021/jo00111a056

upstream raw materials:

3-amino-2-methoxypyridine

di-tert-butyl dicarbonate

tert-butyl chloroformate

Downstream raw materials:

2-Methoxy-4-(phenylmethyl)-3-pyridinecarbamic acid 1,1-dimethylethyl ester

4-Formyl-2-methoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

4-Iodo-2-methoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester

Hexafluoroacetone