3-Butynoic acid, 2-oxo-4-phenyl-, 1-methylethyl ester

Base Information

• Chemical Name: 3-Butynoic acid, 2-oxo-4-phenyl-, 1-methylethyl ester
• CAS No.: 1619-75-6
• Molecular Formula: C13H12O3
• Molecular Weight: 216.236
• Mol file: 1619-75-6.mol

Synonyms:

Chemical Property of 3-Butynoic acid, 2-oxo-4-phenyl-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Butynoic acid, 2-oxo-4-phenyl-, 1-methylethyl ester

There total 2 articles about 3-Butynoic acid, 2-oxo-4-phenyl-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

chlorooxoacetic acid isopropyl ester (26404-20-6) + phenylacetylene (536-74-3) → 2-oxo-4-phenyl-3-butynoic acid isopropyl ester (1619-75-6)

Guidance literature:

With triethylamine; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 12h;

DOI:10.1021/jo0353076

Reference yield:

→ 2-oxo-4-phenyl-3-butynoic acid isopropyl ester (1619-75-6)

Guidance literature:

Ethylmagnesiumbromid/Et2O 1. Phenylacetylen 2. Oxalsaeure-diisopropylester;

Reference yield: 99.0%

N-(5-chloro-2-hydroxybenzylidene)benzohydrazide (19161-62-7) + 2-oxo-4-phenyl-3-butynoic acid isopropyl ester (1619-75-6) → C27H23ClN2O5

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 25 ℃; for 12h; diastereoselective reaction; Sealed tube;

DOI:10.1039/c8cc02565g

upstream raw materials:

chlorooxoacetic acid isopropyl ester

phenylacetylene

Downstream raw materials:

C₂₁H₂₃NO₃

3-phenyl-isoxazole-5-carboxylic acid isopropyl ester

4-Anilino-4-phenyl-buten-⁽³⁾-on-⁽²⁾-saeure-⁽¹⁾-isopropylester

C₂₃H₂₁NO₃