19161-62-7

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 635-93-8 5-chlorosalicyclaldehyde 
• 2420-26-0 4-chlorosalicylaldehyde 
• 553-53-7 Nicotinic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 65-85-0 benzoic acid 

Downstream Products

• 60974-64-3 UO₂(C₁₄H₁₀ClN₂O₂)2 
• 91838-39-0 Zr(OH)2(OC₆H₃ClCHNNHC(O)C₆H₅)2 
• 92909-50-7 (OC₆H₃ClCHNNHCOC₆H₅)2U(OOCCH₃)2 
• 108616-73-5 Fe(O(Cl)C₆H₃CHNNHC(O)C₆H₅)Cl₂(H₂O)=Fe(O(Cl)C₆H₃CHNNHC(O)C₆H₅)Cl₂*H₂O 
• 108616-67-7 Fe(HOClC₆H₃CHNNHC(O)C₆H₅)SO₄(H₂O)=Fe(HOClC₆H₃CHNNHC(O)C₆H₅)SO₄*H₂O 
• 85502-79-0 bis(5-chlorosalicylidene-benzoyl hydrazido)mercury(II) 
• 746619-83-0 di(μ-O)di[nitrato[N-(5-chloro-2-oxy-1-benzylidene)-N'-α-oxybenzylidenehydrazine]copper] 
• 61077-14-3 2-benzoyl-5-chlorobenzaldehyde 

Relevant academic research and scientific papers

Tridentate ONO ligands in vanadium(III-V) complexes - synthesis, characterization and biological activity

The synthesis, properties, including single crystal structures and biological activity of 16 new vanadium complexes with tridentate ONO Schiff base ligands L based on 5-chloro- and 5-hydroxy-salicylaldehyde and selected hydrazides are presented. Several t

BF3-Etherate-catalyzed tandem reaction of 2-formylarylketones with electron-rich arenes/heteroarenes: An assembly of isobenzofurans

An efficient and BF3·Et2O-catalyzed chemoselective synthesis of diversified 1,3-diarylisobenzofuran in a high yield has been described. The reaction proceeds through sequential hydroarylation-cyclization between 2-formylarylketones and electron-rich arenes/heteroarenes. Advantageous features of the developed methodology include operational simplicity, a broad substrate scope, and applicability towards gram scale synthesis. The utility of isobenzofuran derivatives as the diene was extended to the synthesis of [4+2] cyclo-adducts with DMAD and the synthesis of 1,2-dicarbonylarenes in good yields.

Combined Alkylating Agents as a Resolution for Highly Selective N-Alkylation of 2-Hydroxybenzaldehyde Acylhydrazones

Although 2-hydroxybenzaldehyde acylhydrazones, such as salicylaldehyde acylhydrazones, are intriguing bioactive molecules, few of their N-alkylated derivatives are known, and only methyl analogues have been reported previously. We achieved selective N-alk

Organocatalytic synthesis of densely functionalized oxa-bridged 2,6-epoxybenzo[: B] [1,5]oxazocine heterocycles

Metal-free addition of salicylhydrazones to electron deficient internal alkynes catalyzed by 1,4-diazabicyclo[2.2.2]octane (DABCO) to yield oxa-bridged 2,6-epoxybenzo[b][1,5]oxazocine heterocycles was achieved. The demonstrated protocol proceeds through an o-quinone methide formation, aza-Michael addition, stereoselective protonation, enamine promoted aromatization, O,O-acetalization and O,N-aminalization sequence to provide privileged heterocycles in good yields with high diastereoselectivities.

Synthesis of Hydrazide-Containing Chroman-2-ones and Dihydroquinolin-2-ones via Photocatalytic Radical Cascade Reaction of Aroylhydrozones

A general and efficient visible light photocatalytic α-amino carbon radical-based cascade reaction of aroylhydrazones has been described. This protocol tolerates a wide array of α-silylamines and aroylhydrazones to afford the corresponding diversely funct

Synthesis and antifungal activity of substituted salicylaldehyde hydrazones, hydrazides and sulfohydrazides

Efficient synthetic procedures for the preparation of acid hydrazines and hydrazides were developed by converting the corresponding carboxylic acid into the methyl ester catalyzed by Amberlyst-15, followed by a reaction with hydrazine monohydrate. Sulfohydrazides were prepared from the corresponding sulfonyl chlorides and hydrazine monohydrate. Both of these group of compounds were condensed with substituted salicylaldehydes using gradient concentration methods that generated a large library of hydrazone, hydrazide and sulfohydrazide analogs. Antifungal activity of the prepared analogs showed that salicylaldehyde hydrazones and hydrazides are potent inhibitors of fungal growth with little to no mammalian cell toxicity, making these analogs promising new targets for future therapeutic development.

Structural investigations of aroylhydrazones derived from nicotinic acid hydrazide in solid state and in solution

Structural forms of aroylhydrazones derived from nicotinic acid hydrazide have been studied in the solid state by FT-IR spectroscopy and in solution by NMR, UV-Vis and ATR spectroscopy. The studied compounds were N′-benzylidene-3-pyridinecarbohydrazide (1), N′-(2,4- dihydroxyphenylmethylidene)-3-pyridinecarbohydrazide (2), N′-(5-chloro-2- hydroxyphenylmethylidene)-3-pyridinecarbohydrazide (3), and N′-(3,5- dichloro-2-hydroxymethoxyphenylmethylidene)-3-pyridinecarbohydrazide (4). The compound 1 adopted the most stable ketoamine form (form I, CONHNC) in the solid state as well as in various organic solvents. In mixtures of organic solvents with water the UV-Vis and ATR spectra implied intermolecular hydrogen bonding of 1 with water molecules. The presence of both tautomeric forms I and II (form II, COHNNC) was proposed for the solid substance and highly concentrated solutions of 2, whereas form I was detected as the predominant one in diluted solutions. For compounds 3 and 4 a coexistence of forms I and III (form III, CONHNHCCCO) was noticed in the solid state and in polar protic organic solvents. The conversion to form III was induced by increasing the water content in the solvent mixtures. This process was the most pronounced for compound 4. When exposed to daylight, an appearance of a new band was observed during time in the UV-Vis spectrum of 4 in organic solvent/water 1/1 mixtures, which implied that tautomeric interconversion was most likely followed by E/Z isomerisation.

SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER

The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of algae.

SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER

The present invention relates to the use of mixtures containing hydrazone compounds and copper for controlling the growth of fungi.

Magnesium(II), Zinc(II), Cadmium(II), Mercury(II) and Lead(II) Complexes of Salicylidene-Aroyl Hydrazides

Magnesium(II), zinc(II), cadmium(II), mercury(II) and lead(II) complexes of (substituted) salicylidene-benzoyl hydrazide, salicylidene-2-picoloyl hydrazide, salicylidene-2-quinoloyl hydrazide and salicylidene-8-quinoloyl hydrazide schiff bases have been s