ethyl 8-bromo-4-methoxy-5-(1-methylethoxy)naphthalene-2-carboxylate

Base Information

Chemical Name:ethyl 8-bromo-4-methoxy-5-(1-methylethoxy)naphthalene-2-carboxylate
CAS No.:162147-18-4
Molecular Formula:C17H19BrO4
Molecular Weight:367.23400
Hs Code.:

Synonyms:3-Quinolinecarboxylic acid,8-bromo-5-fluoro-4-hydroxy-,ethyl ester;ethyl 8-bromo-5-fluoro-4-hydroxyquinoline-3-carboxylate;

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Chemical Property of ethyl 8-bromo-4-methoxy-5-(1-methylethoxy)naphthalene-2-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:461.197oC at 760 mmHg
Flash Point:232.724oC
PSA：44.76000
Density:1.333g/cm3
LogP:4.57480

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Technology Process of ethyl 8-bromo-4-methoxy-5-(1-methylethoxy)naphthalene-2-carboxylate

There total 7 articles about ethyl 8-bromo-4-methoxy-5-(1-methylethoxy)naphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 77-78-1
dimethyl sulfate

: 162147-17-3
Ethyl 8-bromo-4-hydroxy-5-isopropoxy-2-naphthoate

: 162147-18-4
Ethyl 8-bromo-5-isopropoxy-4-methoxy-2-naphthoate

Guidance literature:: With potassium carbonate; In acetone; for 15h; Heating;
DOI:10.3987/COM-94-S(B)79

Reference yield:

: 75792-33-5
3-isopropoxybenzaldehyde

: 162147-18-4
Ethyl 8-bromo-5-isopropoxy-4-methoxy-2-naphthoate

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / Br₂, NaOAc / CH₂Cl₂

2: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) r.t., overnight

3: 97 percent / 90percent aq. TFA / 3 h

4: 89 percent / 6 h / Heating

5: 95 percent / ethanol / 4 h / Ambient temperature

6: 97 percent / K₂CO₃ / acetone / 10 h / Heating

With bromine; sodium acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; acetone;

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 162147-18-4
Ethyl 8-bromo-5-isopropoxy-4-methoxy-2-naphthoate

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 17 h / 90 °C

2: 62 percent / Br₂, NaOAc / CH₂Cl₂

3: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) r.t., overnight

4: 97 percent / 90percent aq. TFA / 3 h

5: 89 percent / 6 h / Heating

6: 95 percent / ethanol / 4 h / Ambient temperature

7: 97 percent / K₂CO₃ / acetone / 10 h / Heating

With bromine; sodium acetate; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetone;