5-Oxa-2,7-diaza-6-phosphanonanoic acid, 8-methyl-7-(1-methylethyl)-6-(phenylmethoxy)-, phenylmethyl ester

Base Information

• Chemical Name: 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 8-methyl-7-(1-methylethyl)-6-(phenylmethoxy)-, phenylmethyl ester
• CAS No.: 162406-70-4
• Molecular Formula: C23H33N2O4P
• Molecular Weight: 432.5
• Mol file: 162406-70-4.mol

Synonyms:

Chemical Property of 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 8-methyl-7-(1-methylethyl)-6-(phenylmethoxy)-, phenylmethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 8-methyl-7-(1-methylethyl)-6-(phenylmethoxy)-, phenylmethyl ester

There total 2 articles about 5-Oxa-2,7-diaza-6-phosphanonanoic acid, 8-methyl-7-(1-methylethyl)-6-(phenylmethoxy)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

benzyl 2-hydroxyethylcarbamate (77987-49-6) + benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite (108549-21-9) → [2-(benzyloxy-diisopropylamino-phosphanyloxy)-ethyl]-carbamic acid benzyl ester (162406-70-4)

Guidance literature:

With 1H-tetrazole; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/chem.201601326

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → [2-(benzyloxy-diisopropylamino-phosphanyloxy)-ethyl]-carbamic acid benzyl ester (162406-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2 h / 20 °C

2: tetrazole / dichloromethane / 2 h / 20 °C

With sodium hydroxide; In dichloromethane; water;

Reference yield: 78.0%

1,28-dibromo-octacosane (96374-81-1) + [2-(benzyloxy-diisopropylamino-phosphanyloxy)-ethyl]-carbamic acid benzyl ester (162406-70-4) → C108H186N2O16P2

Guidance literature:

1,28-dibromo-octacosane; [2-(benzyloxy-diisopropylamino-phosphanyloxy)-ethyl]-carbamic acid benzyl ester; In dichloromethane; acetonitrile; at 20 ℃; for 16h;

With tert.-butylhydroperoxide; In decane; dichloromethane; acetonitrile; at -40 - 20 ℃; for 2h;

upstream raw materials:

benzyl 2-hydroxyethylcarbamate

benzyl-N,N,N',N'-tetraisopropylphosphorodiamidite

benzyl chloroformate

Downstream raw materials:

(2-{benzyloxy-[(2R,3R)-2,3-dihydroxy-4-(4'-methoxybenzyloxymethyl)-butoxy]-phosphoryloxy}-ethyl)-carbamic acid benzyl ester

(2-{benzyloxy-[(2R,3R)-3-(4'-methoxybenzyloxymethyl)-1,4-dioxa-spiro[4.4]non-2-ylmethoxy]-phosphoryloxy}-ethyl)-carbamic acid benzyl ester

hexadecanoic acid {(1R,2R)-3-[benzyloxy-(2-benzyloxycarbonylamino-ethoxy)-phosphoryloxy]-2-hexadecanoyloxy-1-hydroxymethyl}-propyl ester

hexadecanoic acid {(1R,2R)-3-[benzyloxy-(2-benzyloxycarbonylamino-ethoxy)-phosphoryloxy]-2-hexadecanoyloxy-1-(4'-methoxy-benzyloxymethyl)}-propyl ester