1-(thiophen-2-yl)cyclopropanecarbonitrile

Base Information

• Chemical Name: 1-(thiophen-2-yl)cyclopropanecarbonitrile
• CAS No.: 162959-93-5
• Molecular Formula: C8H7NS
• Molecular Weight: 149.21300
• Hs Code.: 2934999090
• Mol file: 162959-93-5.mol

Synonyms:1-Thien-2-ylcyclopropanecarbonitrile;QC-3120;

Chemical Property of 1-(thiophen-2-yl)cyclopropanecarbonitrile

Chemical Property:

• PSA: 52.03000
• LogP: 2.30328
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Thien-2-ylcyclopropanecarbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Thien-2-ylcyclopropanecarbonitrile is used as a reactant in the preparation of quinolines as P-selectin inhibitors for potential treatment of vascular diseases.

Technology Process of 1-(thiophen-2-yl)cyclopropanecarbonitrile

There total 5 articles about 1-(thiophen-2-yl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-cyanomethylthiophene (20893-30-5) + 1-Bromo-2-chloroethane (107-04-0) → 1-(thiophen-2-yl)cyclopropanecarbonitrile (162959-93-5)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; at 50 ℃;

DOI:10.1021/jm9013696

Reference yield: 100.0%

→ 1-(thiophen-2-yl)cyclopropanecarbonitrile (162959-93-5)

Guidance literature:

Reference yield: 85.0%

2-cyanomethylthiophene (20893-30-5) + diphenyl(vinyl)sulfonium trifluoromethanesulfonate → 1-(thiophen-2-yl)cyclopropanecarbonitrile (162959-93-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 21 ℃; for 12h;

DOI:10.1016/j.tetlet.2018.02.080

upstream raw materials:

2-cyanomethylthiophene

benzyltriethylammonium bromide

ethylene dibromide

1-Bromo-2-chloroethane

Downstream raw materials:

1-(thien-2-yl)cyclopropanecarboxylic acid

9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclopropane-1,4'-thieno[2,3-g]indolizin]-5'-one

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