Refernces
10.1016/S0040-4039(00)95051-2
The research investigates the utility of sodium hydrogen telluride as a nucleophilic reagent for the cleavage of epoxides and quaternary ammonium salts. The purpose of the study was to explore the reagent's ability to open epoxides via an SN2 process to yield telluro-alcohols, which could then be reduced to alcohols using nickel boride. The research also discovered a method to convert telluro-alcohols into olefins with high yield by treatment with p-toluene-sulphonyl chloride in pyridine. Sodium hydrogen telluride was found to be an efficient reagent for the dealkylation of quaternary ammonium salts, a process that complements the classical Emde cleavage and offers the advantage of functionalized cleavage products. The chemicals used in the process include sodium hydrogen telluride, ethanol, 1,2-dibromoethane, nickel boride, pyridine, toluene-p-sulphonyl chloride, and various epoxides and ammonium salts. The conclusions of the study highlight the effectiveness of sodium hydrogen telluride in organic synthesis, particularly in the formation of carbon-tellurium bonds and the conversion of epoxides into alcohols and olefins.
10.1002/ejoc.200701140
The study presents the first synthesis and characterization of open-chain cyclopropylpolyketides through a combination of experimental and computational methods. Researchers synthesized cyclopropylpolyketides by a sequence of chain elongation via acylation and subsequent cyclopropanation. Key chemicals involved include 1(cyclopropyl)butane-1,3-dione and benzoylacetone, which were used as starting materials for cyclopropanation with 1,2-dibromoethane to form cyclopropanes 2a and 2b. These cyclopropanes were then reacted with cyclopropanecarboxylic chloride and benzoyl chloride to produce compounds 3a–c, which were further cyclopropanated to yield the desired cyclopropyltriketides 4a–c. The structure of 4c was confirmed by X-ray crystal structure analysis. Additionally, dimethyl cyclopropane-1,1-dicarboxylate (5) was reacted with 1-cyclopropylethan-1-one to form 7, which was transformed into triketide 8. The study also involved density functional theory computations to analyze the structural and energetic properties of the cyclopropylpolyketides, providing insights into their conformations and stabilities.
10.1007/s10593-007-0156-0
The study focuses on the synthesis and structure of ethyl 2-bromomethyl-5-oxo-1,2,6,7,8,9-hexahydro-5H-oxazolo[3,2-a]quinoline-4-carboxylate, a heterocyclic compound with potential applications in the treatment of bacterial and fungal infections. The researchers used a variety of chemicals, including arylaminomercaptomethylenemalonates, ethylenedibromides, and molecular bromine, to synthesize the target compound through a series of reactions involving protection of mercapto groups, ring closure, and condensation. The study also utilized X-ray analysis and NMR spectroscopy to confirm the structure and stability of the synthesized compound. The purpose of these chemicals was to construct the complex heterocyclic structure of the compound, which is of theoretical interest for establishing structure-activity relationships and searching for novel biologically active materials.
10.1055/s-2002-34837
The research presents a facile and efficient approach to synthesize 4-(2-cyanoethylthio)-1,3-dithiole-2-thione (1), a key compound for the preparation of tetrathiafulvalene (TTF) derivatives, from TBA2[Zn(dmit)2]. The study explores the synthetic conditions for preparing compound 1 and uses it to synthesize new electron donors with two TTF units. The chemicals used in the process include TBA2[Zn(dmit)2], 3-bromopropionitrile, pyridine hydrochloride, Hg(OAc)2, and various electrophilic reagents such as 1,2-dibromoethane and 1,3-dibromopropane. The research concludes that compound 1 can be synthesized with high efficiency using four equivalents of an organic ammonium salt, yielding new electron donors with two TTF units, which are significant for the study of organic conductors and molecular spin-ladder systems.
T,
N,
F
