2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)

Base Information

Chemical Name:2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)
CAS No.:93475-91-3
Molecular Formula:C12H17ClINO3
Molecular Weight:385.6258
Hs Code.:
DSSTox Substance ID:DTXSID40918413

Synonyms:93475-91-3;DTXSID40918413;2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)

Suppliers and Price of 2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)

Chemical Property:

Vapor Pressure:4.31E-06mmHg at 25°C
Boiling Point:383.7°Cat760mmHg
Flash Point:185.9°C
Density:g/cm³
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:384.99417
Heavy Atom Count:18
Complexity:228

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CCOC(=O)COC1=CC=C(C=C1)I.Cl

Technology Process of 2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1)

There total 4 articles about 2-(Dimethylamino)ethyl (4-iodophenoxy)acetate--hydrogen chloride (1/1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 126485-62-9
(4-Trimethylsilanyl-phenoxy)-acetic acid 2-dimethylamino-ethyl ester

: 93475-91-3
(4-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; N-chloro-succinimide; sodium iodide; In acetic acid; at 65 ℃; for 1h;
DOI:10.1248/cpb.37.2276

Reference yield:

: 13132-25-7
4-(trimethylsilyl)phenol

: 93475-91-3
(4-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: NaOC₂H₅ / ethanol / 3 h / Heating

2: 2 N NaOH / 0.5 h

3: 1.) phenyl dichlorophosphate / 1.) DMF, 0-5 deg C, 5 min; 2.) CH₂Cl₂; 3. ) pyridine, 3 h, RT

4: 69 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; sodium ethanolate; O-phenyl phosphorodichloridate; sodium iodide; In ethanol; acetic acid;
DOI:10.1248/cpb.37.2276

Reference yield:

: 126485-60-7
(4-Trimethylsilanyl-phenoxy)-acetic acid

: 93475-91-3
(4-Iodo-phenoxy)-acetic acid 2-dimethylamino-ethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) phenyl dichlorophosphate / 1.) DMF, 0-5 deg C, 5 min; 2.) CH₂Cl₂; 3. ) pyridine, 3 h, RT

2: 69 percent / 1.) N-chlorosuccinimid, NaI; 2.) HCl gas / acetic acid / 1 h / 65 °C

With hydrogenchloride; N-chloro-succinimide; O-phenyl phosphorodichloridate; sodium iodide; In acetic acid;
DOI:10.1248/cpb.37.2276