3,5-DICHLORO-2,4-DIFLUOROBENZOIC ACID

Base Information

• Chemical Name: 3,5-DICHLORO-2,4-DIFLUOROBENZOIC ACID
• CAS No.: 163656-30-2
• Molecular Formula: C7H2Cl2F2O2
• Molecular Weight: 226.994
• Hs Code.: 2916310090
• Mol file: 163656-30-2.mol

Synonyms:3,5-dichloro-2,4-difluorobenzoate;3,5-dichloro-2,4-difluorobenzoic acid;

Chemical Property of 3,5-DICHLORO-2,4-DIFLUOROBENZOIC ACID

Chemical Property:

• PSA: 37.30000
• LogP: 2.96980

Purity/Quality:

99% ^*data from raw suppliers

3,5-Dichloro-2,4-difluorobenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DICHLORO-2,4-DIFLUOROBENZOIC ACID

There total 7 articles about 3,5-DICHLORO-2,4-DIFLUOROBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-(2'-ethylhexyl)-4-dimethylaminopyridinium chloride (92886-00-5) + neopentyl 2,3,4,5-tetrachlorobenzoate (120530-38-3) → 2,4-difluoro-3,5-dichlorobenzoic acid (163656-30-2)

Guidance literature:

With potassium fluoride; In sulfolane;

Reference yield: 35.0%

carbon dioxide (124-38-9,18923-20-1) + 1,3-dichloro-2,4-difluorobenzene (36556-37-3) → 2,4-difluoro-3,5-dichlorobenzoic acid (163656-30-2)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; -78 deg C, 30 min; -78 to 5 deg C;

Reference yield: 12.9%

2,4-difluoro-3-chloro-5-aminobenzoic acid → 2,4-difluoro-3,5-dichlorobenzoic acid (163656-30-2)

Guidance literature:

2,4-difluoro-3-chloro-5-aminobenzoic acid; With hydrogenchloride; copper(l) chloride; In dichloromethane; water; at 0 ℃;

With sodium nitrite; In dichloromethane; water; at 0 - 20 ℃; for 4h;

DOI:10.3184/174751915X14295255352061

upstream raw materials:

carbon dioxide

1,3-dichloro-2,4-difluorobenzene

1-chloro-2,4-difluorobenzene

1-(2'-ethylhexyl)-4-dimethylaminopyridinium chloride