Diethyl 1-benzylhydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: Diethyl 1-benzylhydrazine-1,2-dicarboxylate
• CAS No.: 16396-49-9
• Molecular Formula: C13H18N2O4
• Molecular Weight: 266.297
• DSSTox Substance ID: DTXSID20538234
• Nikkaji Number: J2.758.470E
• Wikidata: Q82413509
• Mol file: 16396-49-9.mol

Synonyms:16396-49-9;DTXSID20538234;Diethyl 1-benzylhydrazine-1,2-dicarboxylate

Chemical Property of Diethyl 1-benzylhydrazine-1,2-dicarboxylate

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 266.12665706
• Heavy Atom Count: 19
• Complexity: 290

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)NN(CC1=CC=CC=C1)C(=O)OCC

Technology Process of Diethyl 1-benzylhydrazine-1,2-dicarboxylate

There total 10 articles about Diethyl 1-benzylhydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

toluene (108-88-3,15644-74-3,16713-13-6) + diethylazodicarboxylate (1972-28-7,218603-74-8) → N-benzyl-N'-(ethoxycarbonyl)ethoxycarbohydrazide (16396-49-9)

Guidance literature:

With copper(I) oxide; 1,10-Phenanthroline; di-tert-butyl peroxide; at 110 ℃; for 28h; Molecular sieve; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1039/c7nj04880g

Reference yield: 68.0%

benzyl bromide (100-39-0) + diethylazodicarboxylate (1972-28-7,218603-74-8) → N-benzyl-N'-(ethoxycarbonyl)ethoxycarbohydrazide (16396-49-9)

Guidance literature:

With ammonium chloride; zinc; In tetrahydrofuran; water; for 0.166667h;

DOI:10.1080/00397911.2013.851245

Reference yield: 52.0%

diethyl hydrazodicarboxylate (4114-28-7) + benzyl bromide (100-39-0) → N-benzyl-N'-(ethoxycarbonyl)ethoxycarbohydrazide (16396-49-9)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol901185d

upstream raw materials:

diethyl diazodicarboxylate

diacetyl peroxide

cyclohexane

toluene

Downstream raw materials:

benzyl-hydrazine-N,N'-dicarboxylic acid dimethyl ester

diethyl 2-benzyl-1-((R)-hydroxymethylallyl)hydrazine-1,2-dicarboxylate