ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate

Base Information

• Chemical Name: ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate
• CAS No.: 17451-67-1
• Molecular Formula: C19H16 N2 O6
• Molecular Weight: 368.346
• Hs Code.: 2925190090
• Mol file: 17451-67-1.mol

Synonyms:2-Isoindolineaceticacid, a-(p-nitrobenzyl)-1,3-dioxo-, ethylester, L- (8CI); NSC 313358

Chemical Property of ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate

Chemical Property:

• Boiling Point: 548°Cat760mmHg
• Flash Point: 285.2°C
• PSA: 109.50000
• Density: 1.396g/cm³
• LogP: 2.82630

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate

There total 27 articles about ethyl (S)-1,3-dihydro-alpha-[(4-nitrophenyl)methyl]-1,3-dioxo-2H-isoindole-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + N-phthaloyl-3-(4-nitrophenyl)-(S)-alanine (17451-66-0,5467-31-2) → N-phthalimido-4-nitro-L-phenylalanine ethyl ester (17451-67-1)

Guidance literature:

With thionyl chloride; for 3h; Reagent/catalyst; Temperature; Reflux;

Reference yield: 92.3%

phthalic anhydride (85-44-9) + ethyl (S)-2-amino-3-(4-nitrophenyl)propionate (34276-53-4,780004-06-0) → N-phthalimido-4-nitro-L-phenylalanine ethyl ester (17451-67-1)

Guidance literature:

phthalic anhydride; ethyl (S)-2-amino-3-(4-nitrophenyl)propionate; With triethylamine; In toluene; at 90 ℃; for 0.2h;

With hydrogenchloride; In water; toluene; at 20 ℃; for 0.5h;

Reference yield: 88.7%

phthalic anhydride (85-44-9) + C11H14N2O4 (780004-06-0) → 4-nitro-N,N-phthaloyl-D-phenylalanin-ethyl ester (6957-95-5,17451-67-1,98722-37-3)

Guidance literature:

phthalic anhydride; C₁₁H₁₄N₂O₄; With triethylamine; In toluene; at 90 ℃; for 0.2h;

With hydrogenchloride; In water; toluene; at 20 ℃; for 0.5h;

upstream raw materials:

N-(2-carboxy-benzoyl)-4-nitro-D-phenylalanine ethyl ester

N-(2-carboxy-benzoyl)-4-nitro-L-phenylalanine ethyl ester

ethanol

(R)-N-phthaloyl-p-nitrophenylalanine

Downstream raw materials:

4-dimethylamino-N,N-phthaloyl-D-phenylalanin-ethyl ester

4-amino-N,N-phthaloyl-D-phenylalanin-ethyl ester

4-dimethylamino-N,N-phthaloyl-L-phenylalanin-ethyl ester

4-diethylamino-L-phenylalanine