4-TERT-BUTYL-4'-FLUOROBENZOPHENONE

Base Information

• Chemical Name: 4-TERT-BUTYL-4'-FLUOROBENZOPHENONE
• CAS No.: 16574-58-6
• Molecular Formula: C17H17FO
• Molecular Weight: 256.32
• Hs Code.: 2914700090
• Mol file: 16574-58-6.mol

Synonyms:p-t-Butyl-p'-fluorbenzophenon;4-TERT-BUTYL-4'-FLUOROBENZOPHENONE;

Chemical Property of 4-TERT-BUTYL-4'-FLUOROBENZOPHENONE

Chemical Property:

• Vapor Pressure: 3.57E-05mmHg at 25°C
• Boiling Point: 353.5oC at 760 mmHg
• Flash Point: 181.2oC
• PSA: 17.07000
• Density: 1.074g/cm3
• LogP: 4.35420

Purity/Quality:

97% ^*data from raw suppliers

4-tert-Butyl-4'-fluorobenzophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TERT-BUTYL-4'-FLUOROBENZOPHENONE

There total 2 articles about 4-TERT-BUTYL-4'-FLUOROBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-fluorobenzoyl chloride (403-43-0) + p-tert-butylphenylboronic acid (123324-71-0) → (4-(tert-butyl)phenyl)(4-fluorophenyl) methanone (16574-58-6)

Guidance literature:

With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 16h;

DOI:10.1021/ja071034a

Reference yield: 69.0%

1-(tert-butyl)-4-(4-fluorobenzyl) benzene → (4-(tert-butyl)phenyl)(4-fluorophenyl) methanone (16574-58-6)

Guidance literature:

With cercosporin; oxygen; potassium bromide; In methanol; at 20 ℃; chemoselective reaction; Irradiation; Schlenk technique; Green chemistry;

DOI:10.1039/c9gc02270h

Reference yield:

(4-(tert-butyl)phenyl)(4-fluorophenyl) methanone (16574-58-6) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → C24H24BrFO

Guidance literature:

1-Bromo-2-bromomethyl-benzene; With magnesium; ethylene dibromide; In diethyl ether; for 5h; Heating;

(4-(tert-butyl)phenyl)(4-fluorophenyl) methanone; In diethyl ether; at 23 ℃; Further stages.;

DOI:10.1021/ja071034a

upstream raw materials:

4-fluorobenzoyl chloride

p-tert-butylphenylboronic acid