[3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone

Base Information

Chemical Name:[3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone
CAS No.:167262-43-3
Molecular Formula:C20H21Cl2NO3
Molecular Weight:394.298
Hs Code.:
DSSTox Substance ID:DTXSID90707935
Mol file:167262-43-3.mol

Synonyms:167262-43-3;SCHEMBL8347632;DTXSID90707935;JGGRFGGHFAYVHR-UHFFFAOYSA-N;[3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone;3-(3,4-dichloro-phenyl)-1-(2-methoxybenzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine

Suppliers and Price of [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:393.0898489
Heavy Atom Count:26
Complexity:492

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1C(=O)N2CCC(C2)(CCO)C3=CC(=C(C=C3)Cl)Cl

Technology Process of [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone

There total 4 articles about [3-(3,4-Dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidin-1-yl](2-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21615-34-9
2-Methoxybenzoyl chloride

: 52423-89-9
3-(3,4-dichloro-phenyl)-3-(2-hydroxy-ethyl)-pyrrolidine

: 167262-43-3
3-(3,4-Dichloro-phenyl)-1-(2-methoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine

Guidance literature:: DOI:10.1016/0960-894X(96)00148-5

Reference yield:

: 40878-10-2
3-cyano-3-(3,4-dichloro-phenyl)-pentanedioic acid diethyl ester

: 167262-43-3
3-(3,4-Dichloro-phenyl)-1-(2-methoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / H₂, NH₄OH / Raney Ni / ethanol

2: 71 percent / AlH₃ / tetrahydrofuran / 50 °C

With aluminium hydride; ammonium hydroxide; hydrogen; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/0960-894X(96)00148-5

Reference yield:

: 3218-49-3
3,4-dichloro-benzeneacetonitrile

: 167262-43-3
3-(3,4-Dichloro-phenyl)-1-(2-methoxy-benzoyl)-3-(2-hydroxy-ethyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / sodium bis(trimethylsilylamide) / tetrahydrofuran

2: 81 percent / H₂, NH₄OH / Raney Ni / ethanol

3: 71 percent / AlH₃ / tetrahydrofuran / 50 °C

With aluminium hydride; ammonium hydroxide; hydrogen; sodium hexamethyldisilazane; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/0960-894X(96)00148-5