40878-10-2

Basic information

• Product Name: Pentanedioic acid, 3-cyano-3-(3,4-dichlorophenyl)-, diethyl ester
• CAS NO: 40878-10-2
• Molecular Formula: C16H17Cl2NO4
• Molecular Weight: 358.221
• Mol File: 40878-10-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Pentanedioic acid, 3-cyano-3-(3,4-dichlorophenyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanedioic acid, 3-cyano-3-(3,4-dichlorophenyl)-, diethyl ester(40878-10-2)
• EPA Substance Registry System: Pentanedioic acid, 3-cyano-3-(3,4-dichlorophenyl)-, diethyl ester(40878-10-2)

Safety Data

• Hazardous Substances Data: 40878-10-2(Hazardous Substances Data)

Upstream product

• 1070-89-9 sodium hexamethyldisilazane 
• 105-36-2 ethyl bromoacetate 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 

Downstream Products

• 40878-11-3 [3-(3,4-dichloro-phenyl)-5-oxo-pyrrolidin-3-yl]-acetic acid ethyl ester 
• 167261-59-8 1-{2-[(S)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl}-4-phenyl-piperidine-4-carboxylic acid amide 
• 167261-59-8 MDL 105212 
• 167262-67-1 (S)-2-[1-(3,4,5-trimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate 
• 177697-11-9 (R)-1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-methanesulfonyloxyethyl)-pyrrolidine 
• 167262-66-0 (S)-1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-hydroxyethyl)pyrrolidine 
• 177697-10-8 (R)-1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3(2-hydroxyethyl)-pyrrolidine 
• 177697-12-0 2-[(S)-3-(3,4-Dichloro-phenyl)-pyrrolidin-3-yl]-ethanol 
• 178961-26-7 2-[(R)-3-(3,4-Dichloro-phenyl)-pyrrolidin-3-yl]-ethanol 
• 167263-26-5 Methanesulfonic acid 2-{3-(3,4-dichloro-phenyl)-1-[2-(3,4,5-trimethoxy-phenyl)-acetyl]-pyrrolidin-3-yl}-ethyl ester 
• 167262-46-6 2-[1-(2,6-Dimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl methanesulfonate 
• 167263-24-3 3-(2-Methanesulfonyloxyethyl)-3-(3,4-dichlorophenyl)-1-(3-isopropoxyphenyl)acetylpyrrolidine 
• 167262-40-0 2-[1-(2,4-Dimethoxy-benzoyl)-3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate 
• 167262-77-3 2-[3-(3,4-dichloro-phenyl)-1-(3,5-dimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl-methanesulfonate 

Relevant articles and documents

NOVEL HETEROCYCLIC SUBSTITUTED PYRROLIDINE AMIDE DERIVATIVES

The present invention relates to novel heterocyclic substituted pyrrolidine amide derivatives of formula (1), and stereoisomers and pharmaceutically acceptable salts thereof and their use as tachykinin receptor antagonists. Such antagonists are useful in the treatment of tachykinin-mediated diseases and conditions disclosed herein including: asthma, cough, and bronchitis.

Novel substituted 4-(1H-benzimidazol-2-yl) [1,4]diazepanes useful for the treatment of allergic diseases

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.

Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease

The present invention relates to novel 4-(1H-benzimidazol-2-yl)[1,4]diazepane derivatives of formula (1): and stereoisomers thereof, and pharmaceutically acceptable salts thereof which are useful as histamine receptor antagonists and tachykinin receptor antagonist. Such antagonists are useful in the treatment of allergic rhinitis, including seasonal rhinitis and sinusitis; inflammatory bowel diseases, including Crohn's disease and ulcerative colitis; asthma; bronchitis; and emesis.