N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

Base Information

Chemical Name:N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide
CAS No.:167837-46-9
Molecular Formula:C₃₃H₃₀Cl₂N₂O₄Si
Molecular Weight:617.604
Hs Code.:

Synonyms:N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

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Chemical Property of N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

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Technology Process of N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

There total 7 articles about N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6780-38-7
N-phthaloylglycine chloride

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 167837-46-9
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112948

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 167837-46-9
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With 1H-imidazole; iron(III) chloride; hydrazine hydrate; triethylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 167837-44-7
tert-butyl(2,6-dichloro-3-nitrobenzyloxy)diphenylsilane

: 167837-46-9
N-(3-((tert-butyldiphenylsilyloxy)methyl)-2,4-dichlorophenyl)-2-(1,3-dioxoisoindol-in-2-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

2: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

With iron(III) chloride; hydrazine hydrate; triethylamine; In methanol; dichloromethane; water;
DOI:10.1021/jm980300f