Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-nitrobenzoyl)amino]benzoyl]-5H- 1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

Base Information

Chemical Name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-nitrobenzoyl)amino]benzoyl]-5H- 1-benzazepin-5-ylidene]-, methyl ester, (2Z)-
CAS No.:168162-82-1
Molecular Formula:C27H21F2N3O6
Molecular Weight:521.477
Hs Code.:
Mol file:168162-82-1.mol

Synonyms:

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Chemical Property of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-nitrobenzoyl)amino]benzoyl]-5H- 1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

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Technology Process of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-nitrobenzoyl)amino]benzoyl]-5H- 1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

There total 3 articles about Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[(2-nitrobenzoyl)amino]benzoyl]-5H- 1-benzazepin-5-ylidene]-, methyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 168163-99-3
(Z)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 168162-82-1
methyl (Z)-[4,4-difluoro-1-[4-(2-nitrobenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃;
DOI:10.1248/cpb.51.1075

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 168163-99-3
(Z)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 168162-82-1
methyl (Z)-[4,4-difluoro-1-[4-(2-nitrobenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

Guidance literature:

Reference yield:

: 552-16-9,104810-18-6
ortho-nitrobenzoic acid

: 168162-82-1
methyl (Z)-[4,4-difluoro-1-[4-(2-nitrobenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride; DMF / CH₂Cl₂ / 20 °C

2: pyridine / CH₂Cl₂ / 20 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1248/cpb.51.1075