Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

Base Information

Chemical Name:Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)-
CAS No.:168162-93-4
Molecular Formula:C26H22F2N2O5
Molecular Weight:480.468
Hs Code.:
Mol file:168162-93-4.mol

Acetic acid,
[4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino
]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

Chemical Property:

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Technology Process of Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)-

There total 6 articles about Acetic acid, [4,4-difluoro-1,2,3,4-tetrahydro-1-[4-[[(3-methyl-2-furanyl)carbonyl]amino ]benzoyl]-5H-1-benzazepin-5-ylidene]-, methyl ester, (2Z)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 22601-06-5
3-methylfuran-2-carbonyl chloride

: 168163-99-3
(Z)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 168162-93-4
methyl (Z)-{4,4-difluoro-1-[4-(3-methylfuran-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃; for 8h;
DOI:10.1016/j.bmc.2005.10.035

Reference yield:

: 4412-96-8
3-methylfuran-2-carboxylic acid

: 168163-99-3
(Z)-methyl [1-(4-aminobenzoyl)-4,4-difluoro-2,3,4,5-tetrahydro-1H-1-benzo-azepine-5-ylidene]acetate

: 168162-93-4
methyl (Z)-{4,4-difluoro-1-[4-(3-methylfuran-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate

Guidance literature:

Reference yield:

: 183171-54-2
methyl (2Z)-(4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetate

: 168162-93-4
methyl (Z)-{4,4-difluoro-1-[4-(3-methylfuran-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / CH₂Cl₂ / 12 h / 20 °C

2: 84 percent / SnCl₂ / ethyl acetate / 5 h / Heating

3: 86 percent / pyridine / acetonitrile / 8 h / 20 °C

With pyridine; tin(ll) chloride; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2005.10.035