22601-06-5

Basic information

• Product Name: 3-METHYLFURAN-2-CARBONYL CHLORIDE
• Synonyms: 3-METHYL-2-FUROYL CHLORIDE;3-METHYLFURAN-2-CARBONYL CHLORIDE;3-METHYLFURAN-2-CARBONYLCHLORIDE,97%;2-METHYLFURAN-2-CARBONYL CHLORIDE 97%;2-Furancarbonyl chloride, 3-Methyl-
• CAS NO: 22601-06-5
• Molecular Formula: C₆H₅ClO₂
• Molecular Weight: 144.56
• Product Categories: API intermediates
• Mol File: 22601-06-5.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 77-78°C 12mm
• Flash Point: 88°C
• Appearance: /
• Density: 1.263
• Vapor Pressure: 0.54mmHg at 25°C
• Refractive Index: 1.5325
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHYLFURAN-2-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLFURAN-2-CARBONYL CHLORIDE(22601-06-5)
• EPA Substance Registry System: 3-METHYLFURAN-2-CARBONYL CHLORIDE(22601-06-5)

Safety Data

• Hazard Codes: Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• WGK Germany: 3
• Hazardous Substances Data: 22601-06-5(Hazardous Substances Data)

Usage

Description

3-Methylfuran-2-carbonyl chloride, with the molecular formula C6H5ClO2, is a reactive acylating agent used in various organic synthesis processes. It is a colorless to light yellow liquid with a pungent odor and is highly flammable. 3-METHYLFURAN-2-CARBONYL CHLORIDE is primarily employed as an intermediate in the production of pharmaceutical products and agrochemicals. Due to its hazardous nature, it should be handled with care to avoid irritation to the skin, eyes, and respiratory system.

Uses

Used in Pharmaceutical Industry:
3-Methylfuran-2-carbonyl chloride is used as an intermediate for the synthesis of various pharmaceutical products. Its acylating properties allow for the formation of new compounds with potential therapeutic applications.
Used in Agrochemical Industry:
3-Methylfuran-2-carbonyl chloride is also utilized as an intermediate in the production of agrochemicals. Its reactivity enables the creation of new compounds with pesticidal or herbicidal properties, contributing to the development of more effective crop protection solutions.
In both industries, 3-Methylfuran-2-carbonyl chloride serves as a crucial building block for the development of new and innovative products, thanks to its unique chemical properties and reactivity. However, its hazardous nature necessitates careful handling and proper safety measures to minimize potential health risks.

InChI:InChI=1/C6H5ClO2/c1-4-2-3-9-5(4)6(7)8/h2-3H,1H3

Upstream product

• 4412-96-8 3-methylfuran-2-carboxylic acid 
• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 33342-48-2 3-methyl-2-furfuraldehyde 
• 930-27-8 3-methylfuran 
• 38435-37-9 ethyl 3-methyl furan-2-carboxylate 

Downstream Products

• 6141-57-7 methyl 3-methylfuran-2-carboxylate 
• 56776-63-7 3-methyl-furan-2-carboxylic acid anilide 
• 856906-98-4 3-methyl-2-furoyl isothiocyanate 
• 168163-18-6 (Z)-{4,4-difluoro-1-[4-(3-methylfuran-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetic acid 
• 168162-93-4 methyl (Z)-{4,4-difluoro-1-[4-(3-methylfuran-2-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate 
• 881309-36-0 methyl (Z)-{4,4-difluoro-1-[4-(2-methylfuran-3-carbonylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene}acetate 
• 488-05-1 3-methyl-1-(3-methylfuran-2-yl)butan-1-one 
• 6138-88-1 3-methyl-1-(3-methylfuran-2-yl)but-2-en-1-one 
• 78173-38-3 3-Methyl-1-(3-methyl-furan-2-yl)-but-3-en-1-one 

Relevant articles and documents

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The synthesis of (-)-cis- and (-)-trans-crobarbatic acid

The synthesis of both cis- and trans-crobarbatic acid is reported. The five-step sequence proceeds in high yield and with control of both relative and absolute stereochemistry. The key step in the synthesis is the Birch reductive alkylation of a chiral furoic acid which sets the absolute stereochemistry of the products. The stereochemistry of the compounds described was proven unambiguously by X-ray crystallography on one synthetic intermediate and on trans-crobarbatic acid.

Palladium-Catalyzed Enantioselective Intramolecular Dearomative Heck Reaction

Enantioselective intramolecular dearomative Heck reactions have been developed by Pd-catalyzed cross-coupling of aryl halides or aryl triflates with the internal C=C bond of indoles, benzofurans, pyrroles, and furans. A variety of structurally unique spir

Conformational effects in diastereoselective aryne diels-alder reactions: synthesis of benzo-fused [2.2.1] heterobicycles

It was found that the diastereoselectivity of the Dials-Alder reaction between arynes and substituted furans Is highly sensitive to substitution, which affects the reactive conformation. By varying the location of the groups on the diene partner, It Is po

Kinase Inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.