Benzenesulfonamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-[(2-methoxyphenyl)thio]-4- pyrimidinyl]-4-(1,1-dimethylethyl)-

Base Information

Chemical Name:Benzenesulfonamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-[(2-methoxyphenyl)thio]-4- pyrimidinyl]-4-(1,1-dimethylethyl)-
CAS No.:169679-45-2
Molecular Formula:C27H28BrN5O5S2
Molecular Weight:646.586
Hs Code.:
Mol file:169679-45-2.mol

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Chemical Property of Benzenesulfonamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-[(2-methoxyphenyl)thio]-4- pyrimidinyl]-4-(1,1-dimethylethyl)-

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Technology Process of Benzenesulfonamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-[(2-methoxyphenyl)thio]-4- pyrimidinyl]-4-(1,1-dimethylethyl)-

There total 8 articles about Benzenesulfonamide, N-[6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-5-[(2-methoxyphenyl)thio]-4- pyrimidinyl]-4-(1,1-dimethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 32779-36-5
5-Bromo-2-chloropyrimidine

: 167403-92-1
4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

: 169679-45-2
4-tert-butyl-N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenylthio)pyrimidin-4-yl}benzenesulfonamide

Guidance literature:: 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide; With sodium hydride; In N,N-dimethyl acetamide; at 20 ℃; for 0.0833333h;

5-Bromo-2-chloropyrimidine; In N,N-dimethyl acetamide; at 20 ℃; for 1h; Further stages.;
DOI:10.1021/jm0102304

Reference yield:

: 15084-51-2
4-tert-butylbenzenesulfonyl chloride

: 169679-45-2
4-tert-butyl-N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenylthio)pyrimidin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / NH₄OH / ethyl acetate / 1 h / 20 °C

2.1: 85 percent / K₂CO₃ / dimethylsulfoxide / 1 h / 80 °C

3.1: NaH / 0.5 h / 20 °C

3.2: 92 percent / 4 h / 100 °C

4.1: NaH / N,N-dimethyl-acetamide / 0.08 h / 20 °C

4.2: 86 percent / N,N-dimethyl-acetamide / 1 h / 20 °C

With ammonium hydroxide; sodium hydride; potassium carbonate; In N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm0102304

Reference yield:

: 13920-94-0
bis(2-methoxyphenyl)disulfide

: 169679-45-2
4-tert-butyl-N-{6-[2-(5-bromopyrimidin-2-yloxy)ethoxy]-5-(2-methoxyphenylthio)pyrimidin-4-yl}benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: SO₂Cl₂; Et₃N / CCl₄ / 0.5 h / 20 °C

2.1: dimethylformamide / 3 h / 20 °C

3.1: 72 percent / POCl₃ / 1 h / Heating

4.1: 85 percent / K₂CO₃ / dimethylsulfoxide / 1 h / 80 °C

5.1: NaH / 0.5 h / 20 °C

5.2: 92 percent / 4 h / 100 °C

6.1: NaH / N,N-dimethyl-acetamide / 0.08 h / 20 °C

6.2: 86 percent / N,N-dimethyl-acetamide / 1 h / 20 °C

With sulfuryl dichloride; sodium hydride; potassium carbonate; triethylamine; trichlorophosphate; In tetrachloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm0102304