4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

Base Information

Chemical Name:4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide
CAS No.:167403-92-1
Molecular Formula:C₂₃H₂₇N₃O₅S₂
Molecular Weight:489.616
Hs Code.:

Synonyms:4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

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Chemical Property of 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

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Technology Process of 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

There total 8 articles about 4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 107-21-1
ethylene glycol

: 167403-91-0
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

: 167403-92-1
4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

Guidance literature:: ethylene glycol; With sodium hydride; at 20 ℃; for 0.5h;

4-tert-butyl-N-(6-chloro-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide; at 100 ℃; for 4h; Further stages.;
DOI:10.1021/jm0102304

Reference yield:

: 25289-18-3,105938-46-3,2836-32-0
sodium glycolate

: 167403-91-0
4-tert-butyl-N-(6-chloro-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

: 167403-92-1
4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

Guidance literature:: With sodium; In ethylene glycol;

Reference yield:

: 15084-51-2
4-tert-butylbenzenesulfonyl chloride

: 167403-92-1
4-tert-butyl-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenyl)thio-4-pyrimidinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / NH₄OH / ethyl acetate / 1 h / 20 °C

2.1: 85 percent / K₂CO₃ / dimethylsulfoxide / 1 h / 80 °C

3.1: NaH / 0.5 h / 20 °C

3.2: 92 percent / 4 h / 100 °C

With ammonium hydroxide; sodium hydride; potassium carbonate; In dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm0102304