5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)-
CAS No.:169960-16-1
Molecular Formula:C32H31N3O5S2
Molecular Weight:601.747
Hs Code.:
Mol file:169960-16-1.mol

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio)
ethenyl]-, diphenylmethyl ester, (6R,7R)-

Synonyms:

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)-

There total 4 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(1,1-dimethylethoxy)carbonyl]amino]-8-oxo-3-[(1E)-2-(4-pyridinylthio) ethenyl]-, diphenylmethyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 4556-23-4
pyridine-4-thiol

: diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(E)-2-(4-toluenesulfonyloxy)vinyl]-3-cephem-4-carboxylate

: 169960-16-1
diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(E)-2-(4-pyridyl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4.5h;
DOI:10.1016/S0968-0896(00)00021-3

Reference yield:

: (6R,7R)-7-tert-Butoxycarbonylamino-5,8-dioxo-3-[(E)-2-(pyridin-4-ylsulfanyl)-vinyl]-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 169960-16-1
diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(E)-2-(4-pyridyl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: With phosphorus trichloride; In tetrahydrofuran; N,N-dimethyl acetamide; at -10 ℃; for 0.583333h;
DOI:10.7164/antibiotics.54.364

Reference yield:

: 4556-23-4
pyridine-4-thiol

: 169960-16-1
diphenylmethyl 7β-tert-butoxycarbonylamino-3-[(E)-2-(4-pyridyl)thiovinyl]-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylsulfoxide / 6 h / 50 °C

2: 45.7 g / PCl₃ / tetrahydrofuran; N,N-dimethyl-acetamide / 0.58 h / -10 °C

With phosphorus trichloride; In tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.7164/antibiotics.54.364