Synonyms:Nitricacid, thallium(3+) salt (8CI,9CI); Thallium nitrate (7CI); Thallic nitrate;Thallium nitrate (Tl(NO3)3); Thallium trinitrate; Thallium(III) nitrate
99%, *data from raw suppliers
The research focuses on the biomimetic synthesis of hexahydrobenzo[c]phenanthridine alkaloids, specifically (+)-corynoline, (+)-ll-epicorynoline, (+)-isocorynoline, and (+)-ll-epiisocorynoline, from the protoberberine alkaloid corysamine. The purpose of this study was to develop a novel and efficient synthetic route that mimics the biogenetic process, providing a general method for the synthesis of these alkaloids. The researchers achieved this by transforming corysamine into the target alkaloids through a series of chemical reactions involving enamine-aldehyde (3) as a proposed biogenetic intermediate. Key chemicals used in the process included thallium (III) nitrate for oxygenation, sodium borohydride, hydrochloric acid, and sodium cyanoborohydride for reduction and cyclization, as well as lithium aluminum hydride and sodium cyanoborohydride for further reduction steps. The conclusions of the study were that the developed synthetic method was not only biomimetic but also simple and efficient, offering a practical approach to synthesizing hexahydrobenzo[c]phenanthridine alkaloids.
The research focused on the synthesis of 9-chloro-10-(4-methylpiperazino)-10,11-dihydrodibenzo[b,f]thiepin (I), a compound belonging to the neurotropic and psychotropic agents class. The study aimed to understand the impact of molecular substitution on the activity of the compound, particularly exploring the effects of chlorine substitution at different positions on the perathiepin molecule. The researchers concluded that substitution at the 9th position of the perathiepin molecule negatively affects the neuroleptic activity, rendering compound I practically inactive as a central depressant and cataleptic agent. Key chemicals used in the synthesis process included 1-chloro-9-methylenethioxanthene (IX), thallic nitrate, methanol, 1-chlorothioxanthone (VI), and various derivatives of dibenzo[b,f]thiepin. The synthesis involved multiple steps, such as oxidation, hydrolysis, and substitution reactions, and utilized various reagents like methylmagnesium iodide, hydrochloric acid, and sulfuric acid, among others.
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