5-Isoxazoleacetic acid, 3-(4-cyanophenyl)-4,5-dihydro-

Base Information

• Chemical Name: 5-Isoxazoleacetic acid, 3-(4-cyanophenyl)-4,5-dihydro-
• CAS No.: 170229-13-7
• Molecular Formula: C12H10N2O3
• Molecular Weight: 230.223
• Mol file: 170229-13-7.mol

Synonyms:

Chemical Property of 5-Isoxazoleacetic acid, 3-(4-cyanophenyl)-4,5-dihydro-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Isoxazoleacetic acid, 3-(4-cyanophenyl)-4,5-dihydro-

There total 7 articles about 5-Isoxazoleacetic acid, 3-(4-cyanophenyl)-4,5-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

[3-(4-Cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester (170229-12-6) → [3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid (170229-13-7)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1021/jm960626t

Reference yield: 50.0%

but-3-enoic acid (625-38-7) + 4-cyanobenzaldehyde oxime (52707-54-7,52707-59-2,64847-77-4) → [3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid (170229-13-7)

Guidance literature:

With sodium hypochlorite; In tetrahydrofuran;

DOI:10.1016/S0960-894X(97)10081-6

Reference yield:

but-3-enoic acid (625-38-7) + 4-Cyanobenzaldoxime (52707-59-2) → [3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid (170229-13-7)

Guidance literature:

With citric acid; In tetrahydrofuran; sodium hypochlorite;

upstream raw materials:

[3-(4-Cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid methyl ester

but-3-enoic acid

4-cyanobenzaldehyde oxime

4-cyanobenzaldehyde

Downstream raw materials:

3-{2-[3-(4-Cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-propionic acid ethyl ester

(R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester

(S)-2-Benzyloxycarbonylamino-3-{2-[3-(4-carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-propionic acid methyl ester

Refernces

• 1、 -. "Isoxazoline and isoxazole fibrinogen receptor antagonists". . . Retrieved 2008/06/13.
• 2、 Quan,Pruitt,Ellis,Liauw,Galemmo Jr.,Stouten,Wityak,Knabb,Thoolen,Wong,Wexler. "Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors". . p. 2813 - 2818. Retrieved 2007/10/03.