(R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester

Base Information

• Chemical Name: (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester
• CAS No.: 190446-76-5
• Molecular Formula: C₂₈H₃₄N₄O₆
• Molecular Weight: 522.601
• Mol file: 190446-76-5.mol

Synonyms:(R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester

Chemical Property of (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester

There total 6 articles about (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl (3R)-3-amino-4-phenylbutanoate (190446-31-2) + (R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetic acid (170726-53-1) → (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester (190446-76-5)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1021/jm960799i

Reference yield:

4-cyanobenzaldehyde oxime (52707-54-7,52707-59-2,64847-77-4) → (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester (190446-76-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 34 percent / aq. NaOCl / tetrahydrofuran / Ambient temperature

2: 73 percent / HCl / 24 h / Ambient temperature

3: NH₃ / methanol / 14 h / Ambient temperature

4: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

5: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

6: 63 percent / TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; sodium hypochlorite; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm960799i

Reference yield:

[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid (170229-13-7) → (R)-3-{2-[3-(4-{Amino-[(E)-tert-butoxycarbonylimino]-methyl}-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-4-phenyl-butyric acid methyl ester (190446-76-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 73 percent / HCl / 24 h / Ambient temperature

2: NH₃ / methanol / 14 h / Ambient temperature

3: 75 percent / Et₃N / dimethylformamide / 16 h / 22 °C

4: 97 percent / aq. LiOH*H₂O / methanol / 16 h / 22 °C

5: 63 percent / TBTU, Et₃N / dimethylformamide / 2 h / Ambient temperature

With hydrogenchloride; lithium hydroxide; ammonia; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm960799i

upstream raw materials:

methyl (3R)-3-amino-4-phenylbutanoate

(R,S)-3-(4-{[N-(dimethylethoxycarbonyl)imino]aminomethyl}phenyl)-4,5-dihydro-5-isoxazoleacetic acid

4-cyanobenzaldehyde oxime

[3-(4-cyano-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetic acid