2,6-Piperidinedione, 3-ethyl-3-(4-nitrophenyl)-, (3R)-

Base Information

• Chemical Name: 2,6-Piperidinedione, 3-ethyl-3-(4-nitrophenyl)-, (3R)-
• CAS No.: 170450-74-5
• Molecular Formula: C13H14N2O4
• Molecular Weight: 262.265
• DSSTox Substance ID: DTXSID30440071
• Nikkaji Number: J860.131C
• Wikidata: Q82256252
• Mol file: 170450-74-5.mol

Synonyms:2,6-PIPERIDINEDIONE, 3-ETHYL-3-(4-NITROPHENYL)-, (3R)-;170450-74-5;SCHEMBL8749759;DTXSID30440071;(3R)-3beta-(4-Nitrophenyl)-3-ethylpiperidine-2,6-dione

Chemical Property of 2,6-Piperidinedione, 3-ethyl-3-(4-nitrophenyl)-, (3R)-

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 262.09535693
• Heavy Atom Count: 19
• Complexity: 396

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)[N+](=O)[O-]
• Isomeric SMILES: CC[C@@]1(CCC(=O)NC1=O)C2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of 2,6-Piperidinedione, 3-ethyl-3-(4-nitrophenyl)-, (3R)-

There total 18 articles about 2,6-Piperidinedione, 3-ethyl-3-(4-nitrophenyl)-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

glutethimide (17575-58-5) → (R)-(+)-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione (170450-74-5)

Guidance literature:

With sulfuric acid; nitric acid; at -10 ℃;

DOI:10.1021/jo00122a064

Reference yield: 80.0%

(R)-(-)-4-cyano-4-(4-nitrophenyl)hexanoic acid → (R)-(+)-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione (170450-74-5)

Guidance literature:

With sulfuric acid; In acetic acid; at 95 ℃; for 2h;

DOI:10.1016/S0040-4020(97)00464-X

Reference yield: 65.0%

(R)-4-cyano-4-(4-nitrophenyl)hexanoic acid cinchonidine salt → (R)-(+)-3-ethyl-3-(4-nitrophenyl)piperidine-2,6-dione (170450-74-5)

Guidance literature:

(R)-4-cyano-4-(4-nitrophenyl)hexanoic acid cinchonidine salt; With hydrogenchloride; In water; toluene; at 20 ℃; Autoclave; Large scale;

With sulfuric acid; at 111 - 112 ℃; Large scale;

DOI:10.1021/op9900075

upstream raw materials:

glutethimide

4,5-Dioxo-3-phenyl-tetrahydro-furan-3-carboxylic acid ethyl ester

(R)-Diethyl 2-phenyl-2-vinylglutarate

(R)-Diethyl 2-phenyl-2-ethylglutarate