1-BOC-3-(2-PYRIDINYLMETHYL)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 1-BOC-3-(2-PYRIDINYLMETHYL)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER
• CAS No.: 170844-67-4
• Molecular Formula: C19H28N2O4
• Molecular Weight: 348.43700
• Mol file: 170844-67-4.mol

Synonyms:

Chemical Property of 1-BOC-3-(2-PYRIDINYLMETHYL)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 68.73000
• LogP: 3.14240

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BOC-3-(2-PYRIDINYLMETHYL)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 1-BOC-3-(2-PYRIDINYLMETHYL)-3-PIPERIDINECARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Bromomethyl)pyridine (55401-97-3) + ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → 3-pyridin-2-ylmethyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (170844-67-4)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at -78 - 0 ℃;

DOI:10.1016/S0960-894X(99)00286-3

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3-pyridin-2-ylmethyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (170844-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: KHMDS / tetrahydrofuran; dimethylformamide / -78 - 0 °C

With potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00286-3

Reference yield:

Ethyl nipecotate (71962-74-8) → 3-pyridin-2-ylmethyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (170844-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: KHMDS / tetrahydrofuran; dimethylformamide / -78 - 0 °C

With potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00286-3

upstream raw materials:

2-(Bromomethyl)pyridine

ethyl N-(t-butyloxycarbonyl)nipecotate

di-tert-butyl dicarbonate

Ethyl nipecotate

Downstream raw materials:

(R)-1-((R)-2-Acetoxy-2-phenyl-acetyl)-3-pyridin-2-ylmethyl-piperidine-3-carboxylic acid ethyl ester

(S)-1-((R)-2-Acetoxy-2-phenyl-acetyl)-3-pyridin-2-ylmethyl-piperidine-3-carboxylic acid ethyl ester

Refernces