55401-97-3

Basic information

• Product Name: 2-(Bromomethyl)pyridine
• Synonyms: Picolyl bromide;2-(Bromomethyl)pyridine;Pyridine, 2-(broMoMethyl)-
• CAS NO: 55401-97-3
• Molecular Formula: C₆H₆BrN
• Molecular Weight: 172.02
• Mol File: 55401-97-3.mol
• Article Data: 21

Chemical Properties

• Melting Point: 115-116 ºC
• Boiling Point: 202 ºC
• Flash Point: 76 ºC
• Appearance: /
• Density: 1.533
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.49±0.12(Predicted)
• CAS DataBase Reference: 2-(Bromomethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Bromomethyl)pyridine(55401-97-3)
• EPA Substance Registry System: 2-(Bromomethyl)pyridine(55401-97-3)

Safety Data

• Hazardous Substances Data: 55401-97-3(Hazardous Substances Data)

Usage

General Description

2-(Bromomethyl)pyridine is a chemical compound that is commonly used in organic synthesis and pharmaceutical research. It is a derivative of pyridine, a six-membered aromatic ring with one nitrogen atom, that has a bromomethyl group attached to the second position of the ring. 2-(Bromomethyl)pyridine is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of complex organic molecules. 2-(Bromomethyl)pyridine is a versatile chemical that is widely employed in the field of medicinal and material chemistry for the development of new drugs and materials.

Upstream product

• 109-06-8 α-picoline 
• 98-98-6 2-Picolinic acid 
• 421552-94-5 2-(bromomethyl)pyridine hydrochloride 
• 31106-82-8 2-(bromomethyl)pyridine hydrobromide 
• 586-98-1 2-Hydroxymethylpyridine 

Downstream Products

• 758706-48-8 5-Nitro-2-[4-(pyridin-2-ylmethoxy)-phenoxy]-pyridine 
• 2044-73-7 2-(sulfanylmethyl)pyridine 
• 1198187-02-8 C₂₄H₂₄N₂O₅ 
• 1206455-31-3 C₁₈H₁₆N₄O₄S 
• 1258781-73-5 (S)-benzyl 2-methyl-1-[1-(pyridin-2-ylmethyl)-1H-imidazol-5-yl]propylcarbamate 
• 1258781-72-4 (S)-benzyl 2-methyl-1-[1-(pyridin-2-ylmethyl)-1H-imidazol-4-yl]propylcarbamate 
• 781650-45-1 tert-butyl ((3R,6S)-(6-(2,3-difluorophenyl)-2-oxo-1-(pyridin-2-ylmethyl)azepan-3-yl))carbamate 
• 1415048-95-1 6,6'-[3-aza(pyridine-2-ylmethyl)penta-1,5-di-yl]-1',2,3,3',4,4'-hexa-O-benzylsucrose 
• 62154-62-5 2-[(1H-imidazol-1-yl)methyl]pyridine 
• 1581695-80-8 1-(diphenylcarbamoyl-methyl)-3-pyridylmethyl-imidazoliumbromide 
• 1581695-83-1 1-phenylcarbamoylmethyl-3-pyridylmethyl-3H-imidazoliumbromide 
• 179687-79-7 2-((2-chloro-4-nitrophenoxy)methyl)pyridine 
• 926240-98-4 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde 

Relevant articles and documents

Room-temperature Pd-catalyzed methoxycarbonylation of terminal alkynes with high branched selectivity enabled by bisphosphine-picolinamide ligand

We report the room-temperature Pd-catalyzed methoxy-carbonylation with high branched selectivity using a new class of bisphosphine-picolinamide ligands. Systematic optimization of ligand structures and reaction conditions revealed the significance of both

TBAB-Catalyzed Csp3–N Bond Formation by Coupling Pyridotriazoles with Anilines: A New Route to (2-Pyridyl)alkylamines

A new metal-free procedure allowing Csp3–N bond formation through coupling of pyridotriazoles and weakly nucleophilic anilines has been developed. This sustainable reaction shows high tolerance towards functional groups (ketones, free alcohols) leading to 2-picolylamine derivatives. The key to our success is the use of a catalytic amount of TBAB and water as a co-solvent leading to the formation of pyridylalkylamine derivatives. As this coupling tolerates the presence of Csp2–Br bond on both partners of the reaction, we performed a sequential one-pot reaction between functionalized triazolopyridines and anilines followed by a second coupling with N-tosylhydrazones leading to the formation of Csp3–N and Csp2–Csp2 bonds.

Synthesis method of 2-methoxy methylpyridine

The invention relates to the field of organic chemistry and particularly relates to a synthesis method of 2-methoxy methylpyridine. The method comprises the following steps of (1) adopting 2-methylpyridine as a raw material and obtaining 2-bromo-methylpyridine through bromination reaction; (2) reacting the 2-bromo-methylpyridine and trimethylamine to obtain (2-pyridine methyl) trimethyl ammonium bromide; and (3) dissolving the (2-pyridine methyl) trimethyl ammonium bromide into methanol, adding sodium methoxide and carrying out heating refluxing under nitrogen for 1h to obtain the 2-methoxy methylpyridine. After adopting the synthesis method, the 2-methylpyridine is taken as the raw material, the 2-bromo-methylpyridine is obtained through bromination reaction, and the (2-pyridine methyl) trimethyl ammonium bromide is obtained through trimethylamine reaction and finally reacts with the sodium methoxide to obtain the 2-methoxy methylpyridine. The synthesis method is high in total yield, cheap in raw material, short in reaction time, mild in condition and simple in technological operation.