2-(phenylsulfonyl)-3-(2-thienyl)acrylonitrile

Base Information

Chemical Name:2-(phenylsulfonyl)-3-(2-thienyl)acrylonitrile
CAS No.:17096-73-0
Molecular Formula:C13H9NO2S2
Molecular Weight:275.352
Hs Code.:
Mol file:17096-73-0.mol

Synonyms:(E)-2-Benzenesulfonyl-3-thiophen-2-yl-acrylonitrile;2-benzenesulfonyl-3-thiophen-2-yl-acrylonitrile;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(phenylsulfonyl)-3-(2-thienyl)acrylonitrile

Chemical Property:

Melting Point:121 - 122 °C (hexane)
PSA：94.55000
LogP:4.16728

Purity/Quality:

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Technology Process of 2-(phenylsulfonyl)-3-(2-thienyl)acrylonitrile

There total 1 articles about 2-(phenylsulfonyl)-3-(2-thienyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 98-03-3
thiophene-2-carbaldehyde

: 7605-28-9
2-(phenylsulfonyl)acetonitrile

: 17096-73-0
α-phenylsulfonyl-3-(2-thiophenyl)acrylonitrile

Guidance literature:: With piperidine; acetic acid; In toluene; for 24h; Reflux; Dean-Stark;
DOI:10.1021/ol400356k

Reference yield:

: 873-83-6
4-Amino-2,6-dihydroxypyrimidine

: 17096-73-0
α-phenylsulfonyl-3-(2-thiophenyl)acrylonitrile

: 7?amino?6?(phenylsulfonyl)?5?(thiophen?2?yl)?6,8a?dihydropyrido[2,3?d]pyrimidine?2,4(1H,3H)?dione

Guidance literature:: In glycerol; at 80 ℃; Green chemistry;
DOI:10.1007/s13738-018-1528-3

Reference yield:

: 1362309-60-1
(E)-ethyl 6-nitrohex-2-enoate

: 17096-73-0
α-phenylsulfonyl-3-(2-thiophenyl)acrylonitrile

: 1426537-02-1
(+)-ethyl 2-(2R-cyano-4S-nitro-3R-(2-thiophenyl)-2R-(phenylsulfonyl)-1S-cyclohexyl) acetate

: 1426537-12-3
ethyl 2-(2R-cyano-4S-nitro-3R-(2-thiophenyl)-2R-(phenylsulfonyl)-1R-cyclohexyl) acetate

: ethyl 2-(2S-cyano-4R-nitro-3S-(2-thiophenyl)-2S-(phenylsulfonyl)-1R-cyclohexyl)acetate

Guidance literature:: With C₂₉H₂₈F₆N₄OS; In diethyl ether; at 20 ℃; for 84h; Overall yield = 76 %; Overall yield = 188 mg; stereoselective reaction;
DOI:10.1021/ol400356k