4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine

Base Information

• Chemical Name: 4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine
• CAS No.: 153526-67-1
• Molecular Formula: C₂₅H₃₂N₂O₂
• Molecular Weight: 392.541
• Mol file: 153526-67-1.mol

Synonyms:4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine

Chemical Property of 4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 545.378°C at 760 mmHg
• PKA: 7.88±0.10(Predicted)
• Flash Point: 283.634°C
• PSA: 24.94000
• Density: 1.109g/cm³
• LogP: 4.63870

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine

There total 2 articles about 4-(3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl)-1-(2-pyridyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Methoxy-1-tetralone (33892-75-0) → 4-<3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl>-1-(2-methoxyphenyl)piperazine (153526-67-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Mg, 2.) 20percent aq. HBr / 1.) THF, reflux, 2 h, 2.) THF, acetic acid, RT, day

2: sodium carbonate / dimethylformamide / Heating

With hydrogen bromide; sodium carbonate; magnesium; In N,N-dimethyl-formamide;

DOI:10.1021/jm00027a012

Reference yield:

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 4-(3-bromo-n-propyl)-1,2-dihydro-8-methoxynaphthalene (153526-80-8) → 4-<3-(1,2-dihydro-8-methoxynaphthalen-4-yl)-n-propyl>-1-(2-methoxyphenyl)piperazine (153526-67-1)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; Yield given; Heating;

DOI:10.1021/jm00027a012

upstream raw materials:

1-(2-Methoxyphenyl)piperazine

4-(3-bromo-n-propyl)-1,2-dihydro-8-methoxynaphthalene

5-Methoxy-1-tetralone