Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-

Base Information

• Chemical Name: Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-
• CAS No.: 172424-27-0
• Molecular Formula: C11H11F3O2
• Molecular Weight: 232.202
• Mol file: 172424-27-0.mol

Synonyms:

Chemical Property of Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)-

There total 11 articles about Benzenemethanol, a-methyl-4-(trifluoromethyl)-, acetate, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Isopropenyl acetate (108-22-5) + 1-(4-trifluorophenyl)ethanol (1737-26-4) → (S)-1-(4-trifluoromethylphenyl)ethanol (99493-93-3) + (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (1737-26-4,68120-43-4,99493-93-3,76155-79-8) + (R)-1-acetoxy-1-(4-trifluoromethylphenyl)ethane (172424-27-0)

Guidance literature:

With Candida antarctica lipase B; dicarbonyl(chloro)(η⁵-pentaphenylcyclopentadienyl)ruthenium(II); potassium tert-butylate; sodium carbonate; In tetrahydrofuran; toluene; at 20 ℃; for 24h;

DOI:10.1021/ja051576x

Reference yield: 98.0%

Isopropenyl acetate (108-22-5) + 1-(4-trifluorophenyl)ethanol (1737-26-4) → (R)-1-acetoxy-1-(4-trifluoromethylphenyl)ethane (172424-27-0)

Guidance literature:

With Candida antarctica lipase B; potassium tert-butylate; sodium carbonate; RuCl(CO)2(η⁵-C5Ph5); In tetrahydrofuran; toluene; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.05.175

Reference yield: 92.0%

4-chlorophenyl acetate (876-27-7) + 1-(4-trifluorophenyl)ethanol (1737-26-4) → (R)-1-acetoxy-1-(4-trifluoromethylphenyl)ethane (172424-27-0)

Guidance literature:

1-(4-trifluorophenyl)ethanol; With dicarbonylhydro[2,5-di(trimethylsilyl)-3,4-butylene-1-hydroxy(η5-cyclopentadienyl)]iron; lipase from Candida antarctica; In toluene; for 0.0833333h; Schlenk technique; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

4-chlorophenyl acetate; In toluene; at 60 ℃; for 24h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201606197

upstream raw materials:

Isopropenyl acetate

1-(4-trifluorophenyl)ethanol

vinyl acetate

4-chlorophenyl acetate

Downstream raw materials:

(R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol