99493-93-3

Basic information

• Product Name: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL
• Synonyms: S-PTF-PEL;(S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL;(1S)-1-[4-(Trifluoromethyl)phenyl]ethan-1-ol;(-)-1-(p-Trifluoromethylphenyl)ethanol;(S)-1-[p-(Trifluoromethyl)phenyl]ethanol;(R)-alpha-Methyl-4-(trifluoromethyl)benzyl alcohol, 4-[(1S)-1-Hydroxyethyl]benzotrifluoride;Benzenemethanol, a-methyl-4-(trifluoromethyl)-, (aS)-
• CAS NO: 99493-93-3
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.16
• Mol File: 99493-93-3.mol
• Article Data: 251

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.234
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.98±0.20(Predicted)
• CAS DataBase Reference: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(99493-93-3)
• EPA Substance Registry System: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(99493-93-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 99493-93-3(Hazardous Substances Data)

Usage

General Description

(S)-1-[4-(trifluoromethyl)phenyl]ethanol is a chemical compound with the molecular formula C10H11FO. It is a white to light yellow solid that is used in various scientific research and chemical synthesis processes. It belongs to the class of organic compounds known as aromatic alcohols, which are compounds containing both an aromatic ring and a hydroxyl group. (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL has a trifluoromethyl group attached to the phenyl ring, which gives it unique chemical properties. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its precise applications and uses depend on the specific research or industrial process in which it is being employed.

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 108-05-4 vinyl acetate 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 108-24-7 acetic anhydride 
• 69638-96-6 isopropenyl valerate 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 98-88-4 benzoyl chloride 
• 97-72-3 2-Methylpropionic anhydride 
• 876-27-7 4-chlorophenyl acetate 
• 67-63-0 isopropyl alcohol 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 917-54-4 methyllithium 

Downstream Products

• 306296-86-6 [(1R)-1-[4-(trifluoromethyl)phenyl]ethyl] methanesulfonate 
• 666824-77-7 triethyl (2S)-2-[4-(trifluoromethyl)phenyl]propane-1,1,1-tricarboxylate 
• 1737-26-4 (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol 
• 306296-89-9 (S)-2-Methyl-1-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine 
• 306296-88-8 (S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 306296-87-7 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine 
• 306297-00-7 tert-butyl 4-methyl-4-((S)-3-methyl-4-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)piperidine-1-carboxylate 
• 306296-99-1 4-Cyano-4-{(S)-3-methyl-4-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester 
• 306293-36-7 Sch 350581 
• 306293-41-4 Sch 350634 
• 544704-12-3 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine 
• 854738-78-6 methyl ((1R,4S)-6-fluoro-4-hydroxy-8-(methylsulfonyl)-9-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-2,3,4,9-tetrahydro-1H-carbazol-1-yl) acetate 
• 1195962-53-8 (R)-(1E)-1-(1-(4-(trifluoromethyl)phenyl)ethoxy)-2-methylpent-1-en-3-one 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 

Relevant articles and documents

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

Polydopamine-Encapsulated Dendritic Organosilica Nanoparticles as Amphiphilic Platforms for Highly Efficient Heterogeneous Catalysis in Water

Aqueous heterogeneous catalysis is a green, sustainable catalytic process that attracts increasing attention, but it often suffers from poor mass transfer, substrate adsorption and catalyst dispersion. Herein, we synthesized a type of amphiphilic core-shell catalysts with a hydrophilic polydopamine (PDA) shell and a hydrophobic dendritic organosilica nanoparticle (DON) core for heterogeneous catalysis in water. The hydrophilic shell allowed the catalyst dispersing well in water, and the hydrophobic core facilitated the absorption of organic reactants. The hierarchical core-shell structure facilitated rational arrangement of the location of catalytic species to match the reaction sequence. The obtained metal, enzyme and metal-enzyme amphiphilic catalysts demonstrated improved stability, selectivity and activity in aqueous reactions, including Pd-catalyzed cross-couplings (Suzuki, Liebeskind-Srogl, Heck and Sonogashira), enzymatic enantioselective reduction, chemoenzymatic cascade synthesis of chiral compounds and chemoenzymatic cascade degradation of organophosphates. The amphiphilic catalysts could be easily in situ recovered, and their high catalytic performance was sustained for five cycles.

PQXdpap: Helical Poly(quinoxaline-2,3-diyl)s Bearing 4-(Dipropylamino)pyridin-3-yl Pendants as Chirality-Switchable Nucleophilic Catalysts for the Kinetic Resolution of Secondary Alcohols

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-(dipropylamino)pyridin-3-yl pendants at the 5-position of the quinoxaline ring (PQXdpap) exhibited high catalytic activities and moderate to high selectivities (up to s = 87) in the acylative kinetic resolution of secondary alcohols. The solvent-dependent helical chirality switching of PQXdpap between pure toluene and a 1:1 mixture of toluene and 1,1,2-trichloroethane enabled the preparation of either compound of a pair of enantiomerically pure alcohols (>99% ee) from a single catalyst.