Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS No.:172531-76-9
Molecular Formula:C52H66N5O8PSSi
Molecular Weight:980.25
Hs Code.:

Cytidine,
N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl
ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl
bis(1-methylethyl)phosphoramidite]

Synonyms:

Suppliers and Price of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 9 articles about Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-4'-thio-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 159981-11-0
N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine

: 172531-76-9
N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine

Guidance literature:: With 1-methyl-1H-imidazole; 1H-tetrazole; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm050822c

Reference yield: 89.0%

: 2-cyanoethoxy-N,N,N',N'-tetraisopropylphosphoramidite

: 159981-11-0
N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine

: 172531-76-9
N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine

Guidance literature:: With 1-methyl-1H-imidazole; 1H-tetrazole; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 8h;

Reference yield:

: 149359-06-8
1-[5-(4,4'-dimethoxytrityl)-3-(t-butyldimethylsilyl)-4-thio-beta-D-ribofuranosyl]uracil

: 172531-76-9
N⁴-benzoyl-1-[2-O-(tert-butyldimethylsilyl)-3-O-[(2-cyanoethyl)(N,N-diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-4-thio-β-D-ribofuranosyl]cytosine

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole; pyridine / 24 h / 20 °C

2.1: 1,2,4-triazole; POCl₃; Et₃N / acetonitrile / 20 °C

2.2: aq. NH₃ / dioxane

3.1: pyridine

4.1: 13 g / triethylamine trihydrofluoride; triethylamine / tetrahydrofuran / 20 °C

5.1: pyridine; AgNO₃ / tetrahydrofuran / 0.5 h / 20 °C

5.2: 47 percent / tetrahydrofuran / 20 °C

6.1: Et₃N; imidazole / ethanol

7.1: 94 percent / tetrazole; N-methylimidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; 1,2,4-Triazole; 1-methyl-1H-imidazole; 1H-tetrazole; triethylamine trihydrofluoride; silver nitrate; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm050822c