(3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione

Base Information

Chemical Name:(3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione
CAS No.:172721-98-1
Molecular Formula:C15H19NO3
Molecular Weight:261.321
Hs Code.:
DSSTox Substance ID:DTXSID101318619
Nikkaji Number:J2.175.278I
Wikidata:Q105351363

Synonyms:(3r,6r)-3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione;DTXSID101318619;HY-121407;3beta-Benzyl-4-methyl-6beta-isopropylmorpholine-2,5-dione;172721-98-1

Suppliers and Price of (3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione

Chemical Property:

PSA：46.61000
LogP:1.57540
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:261.13649347
Heavy Atom Count:19
Complexity:347

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1C(=O)N(C(C(=O)O1)CC2=CC=CC=C2)C
Isomeric SMILES:CC(C)[C@@H]1C(=O)N([C@@H](C(=O)O1)CC2=CC=CC=C2)C

Technology Process of (3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione

There total 2 articles about (3r,6r)-3-Benzyl-6-isopropyl-4-methylmorpholine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114526-00-0
(2R)-2-[[(benzyloxy)carbonyl](methyl)amino]-3-phenylpropanoic acid

: 172721-98-1,65454-13-9
(3R, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / DMAP, DCC / CH₂Cl₂

2: 1.) H₂, 2.) N-hydroxysuccinimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / 1.) Pd-C / 1.) EtOH, rt, 2.) DMF, rt

With dmap; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane;
DOI:10.7164/antibiotics.48.1407

Reference yield:

: N-benzyloxycarbonyl-N-methyl-D-<(1-benzyloxycarbonyl-2-methyl)propyl> phenylalanate

: 65454-13-9
(3R,6S)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

: 172721-98-1,65454-13-9
(3R, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; Yield given. Multistep reaction. Yields of byproduct given; 1.) EtOH, rt, 2.) DMF, rt;
DOI:10.7164/antibiotics.48.1407