lateritin

Base Information

• Chemical Name: lateritin
• CAS No.: 65454-13-9
• Molecular Formula: C₁₅H₁₉NO₃
• Molecular Weight: 261.321
• Hs Code.: 29419000
• Mol file: 65454-13-9.mol

Synonyms:Lateritin;Lateritine

Chemical Property of lateritin

Chemical Property:

• Vapor Pressure: 1.57E-08mmHg at 25°C
• Boiling Point: 456.8°C at 760 mmHg
• Flash Point: 230.1°C
• PSA: 46.61000
• Density: 1.126g/cm³
• LogP: 1.57540

Purity/Quality:

99% ^*data from raw suppliers

(3S,6R)-LATERITIN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of lateritin

There total 14 articles about lateritin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(3S,6S)-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione + methyl iodide (74-88-4) → (3S, 6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (65454-13-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.7164/antibiotics.48.1407

Reference yield: 57.0%

(3R,6S)-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione (150933-99-6) + methyl iodide (74-88-4) → (3R,6S)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione (65454-13-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; paraffin; for 0.25h; Ambient temperature;

DOI:10.7164/antibiotics.48.1407

Reference yield:

(S)-2-Hydroxy-3-methylbutanoic acid (17407-55-5) → (3R,6S)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione (65454-13-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / N-methylmorpholine, N-hydroxysuccinimide, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / tetrahydrofuran / 17 h / Ambient temperature

2: 99 percent / H₂ / Pd-C / ethanol / 4 h / Ambient temperature

3: 79 percent / p-TsOH*H₂O / benzene / 4 h / Heating

4: 57 percent / NaH / dimethylformamide; paraffin / 0.25 h / Ambient temperature

With 4-methyl-morpholine; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; sodium hydride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; paraffin; benzene;

DOI:10.7164/antibiotics.48.1407

upstream raw materials:

(3R,6S)-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

methyl iodide

(S)-2-Hydroxy-3-methylbutanoic acid

(R)-phenylalanine benzyl ester p-toluenosulfonate

Downstream raw materials:

(R)-2-Hydroxy-3-methylbutyric acid

N-Methyl-L-phenylalanine