1H-Isoindol-1-one, 2,3-dihydro-2-(2-methylphenyl)-

Base Information

• Chemical Name: 1H-Isoindol-1-one, 2,3-dihydro-2-(2-methylphenyl)-
• CAS No.: 17372-63-3
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Mol file: 17372-63-3.mol

Synonyms:

Chemical Property of 1H-Isoindol-1-one, 2,3-dihydro-2-(2-methylphenyl)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Isoindol-1-one, 2,3-dihydro-2-(2-methylphenyl)-

There total 9 articles about 1H-Isoindol-1-one, 2,3-dihydro-2-(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

o-toluidine (95-53-4) + o-carboxybenzaldehyde (119-67-5) → 2-(o-methylphenyl)phthalimidine (17372-63-3)

Guidance literature:

With (dipyridylamine)Cp*IrOSO₃; hydrogen; In neat (no solvent); at 110 ℃; for 16h; under 3750.38 Torr; chemoselective reaction; Autoclave;

DOI:10.1002/cssc.201701299

Reference yield: 86.0%

carbon monoxide (201230-82-2) + ortho-bromobenzaldehyde (6630-33-7) + o-toluidine (95-53-4) → 2-(o-methylphenyl)phthalimidine (17372-63-3)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 24h; under 7600.51 Torr; Autoclave;

DOI:10.1016/j.tetlet.2009.02.109

Reference yield: 80.0%

2-methyl-N-(2-methylphenyl)benzamide (22978-49-0) → 2-(o-methylphenyl)phthalimidine (17372-63-3)

Guidance literature:

2-methyl-N-(2-methylphenyl)benzamide; With iodine; potassium carbonate; In acetonitrile; at 20 ℃; for 0.166667h; Sealed tube;

With di-tert-butyl peroxide; In acetonitrile; at 140 ℃; Sealed tube;

DOI:10.1039/c4cc08717h

upstream raw materials:

o-toluidine

o-phthalic dicarboxaldehyde

carbon monoxide

ortho-bromobenzaldehyde