4-Bromo-2-fluorothiophenol

Base Information

• Chemical Name: 4-Bromo-2-fluorothiophenol
• CAS No.: 174414-93-8
• Molecular Formula: C6H4BrFS
• Molecular Weight: 207.066
• Hs Code.: 2930909090
• Mol file: 174414-93-8.mol

Synonyms:4-Bromo-2-fluorothiophenol;Benzenethiol,4-bromo-2-fluoro;

Chemical Property of 4-Bromo-2-fluorothiophenol

Chemical Property:

• Vapor Pressure: 0.122mmHg at 25°C
• PSA: 38.80000
• LogP: 2.87690
• Storage Temp.: 2-8°C

Purity/Quality:

95%, ^*data from raw suppliers

4-Bromo-2-fluorothiophenol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-fluorothiophenol

There total 4 articles about 4-Bromo-2-fluorothiophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 4-bromo-2-fluorobenzenethiol (174414-93-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 8.25h;

Reference yield: 92.0%

C9H9BrFNOS (190649-00-4) → 4-bromo-2-fluorobenzenethiol (174414-93-8)

Guidance literature:

C₉H₉BrFNOS; With sodium hydroxide; water; In methanol; for 5h; Heating / reflux;

With sodium hydrogen sulfate; In methanol; water; at 20 ℃;

Reference yield:

4-bromo-2-fluorobenzenesulfonyl chloride (216159-03-4) → 4-bromo-2-fluorobenzenethiol (174414-93-8)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18.25h;

upstream raw materials:

C₉H₉BrFNOS

4-bromo-2-fluorobenzenesulfonyl chloride

Downstream raw materials:

3-((4-bromo-2-fluorophenyl)thio)propanoic acid

Refernces

• 1、 -. "BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE". Page/Page column 33-34. . Retrieved 2008/06/13.
• 2、 -. "Sulfonyl pyridazinone compounds useful as aldose reductase inhibitors". . . Retrieved 2008/06/13.