1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine

Base Information

Chemical Name:1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
CAS No.:174643-75-5
Molecular Formula:C27H31NO
Molecular Weight:385.549
Hs Code.:
UNII:N3ZVN378F4
DSSTox Substance ID:DTXSID80433271
Nikkaji Number:J728.069F
Wikipedia:1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine
Wikidata:Q4545769
ChEMBL ID:CHEMBL338733

Synonyms:1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine;174643-75-5;CHEMBL338733;4-(2-(Diphenylmethoxy)ethyl)-1-(phenylmethyl)piperidine;4-[2-(diphenylmethoxy)ethyl]-1-(phenylmethyl)piperidine;N3ZVN378F4;SCHEMBL1239701;DTXSID80433271;BDBM50049362;ICX5609014;1-Benzyl-4-[2-(benzhydryloxy)ethyl]piperidine;4-(2-Benzhydryloxy-ethyl)-1-benzyl-piperidine;Q4545769;Piperidine, 4-(2-(diphenylmethoxy)ethyl)-1-(phenylmethyl)-

Suppliers and Price of 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine

Chemical Property:

XLogP3:5.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:385.240564612
Heavy Atom Count:29
Complexity:408

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1CCOC(C2=CC=CC=C2)C3=CC=CC=C3)CC4=CC=CC=C4

Technology Process of 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine

There total 6 articles about 1-Benzyl-4-(2-(diphenylmethoxy)ethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 91-01-0
1,1-Diphenylmethanol

: 76876-70-5
N-benzyl-4-(2-hydroxyethyl)piperidine

: 174643-75-5
4-[2-(Diphenylmethoxy)ethyl]-1-(phenylmethyl)piperidine

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Heating;
DOI:10.1021/jm9506581

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 174643-75-5
4-[2-(Diphenylmethoxy)ethyl]-1-(phenylmethyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h

2: 91 percent / LAH / tetrahydrofuran / 2 h / Heating

3: 46 percent / p-toluenesulfonic acid / benzene / Heating

With lithium aluminium tetrahydride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; benzene;
DOI:10.1021/jm9506581

Reference yield:

: 100-39-0
benzyl bromide

: 174643-75-5
4-[2-(Diphenylmethoxy)ethyl]-1-(phenylmethyl)piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / dimethylformamide / 70 °C

2: aq.HCl / benzene / 24 h / Heating

3: 1.) NaH / 1.)a) THF, RT, 10 min, b) reflux, 15 min, 2.) THF, reflux, 1.5 h

4: 91 percent / LAH / tetrahydrofuran / 2 h / Heating

5: 46 percent / p-toluenesulfonic acid / benzene / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm9506581