9,9-Dimethyl-2-phenyl-9H-fluorene

Base Information

• Chemical Name: 9,9-Dimethyl-2-phenyl-9H-fluorene
• CAS No.: 174753-91-4
• Molecular Formula: C21H18
• Molecular Weight: 270.374
• DSSTox Substance ID: DTXSID60601355
• Nikkaji Number: J2.008.945H
• Wikidata: Q82497962
• Mol file: 174753-91-4.mol

Synonyms:9,9-DIMETHYL-2-PHENYL-9H-FLUORENE;174753-91-4;9H-Fluorene, 9,9-dimethyl-2-phenyl-;9,9-DIMETHYL-2-PHENYLFLUORENE;DTXSID60601355;REEQYOKOKNXMAG-UHFFFAOYSA-N;G71643

Chemical Property of 9,9-Dimethyl-2-phenyl-9H-fluorene

Chemical Property:

• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 1
• Exact Mass: 270.140850574
• Heavy Atom Count: 21
• Complexity: 362

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C2=CC=CC=C2C3=C1C=C(C=C3)C4=CC=CC=C4)C

Technology Process of 9,9-Dimethyl-2-phenyl-9H-fluorene

There total 4 articles about 9,9-Dimethyl-2-phenyl-9H-fluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-trifluoromethanesulfony-(9,9-dimethyl-9H-fluoren-2-yl)amine + phenylmagnesium bromide (100-58-3) → 9,9-dimethyl-7-phenyl-9H-fluorene (174753-91-4)

Guidance literature:

N-trifluoromethanesulfony-(9,9-dimethyl-9H-fluoren-2-yl)amine; phenylmagnesium bromide; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Schlenk technique; Inert atmosphere;

With bis(tricyclohexylphosphine)nickel(II) dichloride; 1,3-di-cyclohexyl-4-methyl-benzimidazolium chloride; In toluene; butan-1-ol; at 70 ℃; for 12.03h; Schlenk technique; Inert atmosphere; Glovebox;

DOI:10.1021/acs.orglett.0c03660

Reference yield: 82.0%

2-bromo-9,9-dimethyl-9H-fluorene (28320-31-2) + phenylboronic acid (98-80-6) → 9,9-dimethyl-7-phenyl-9H-fluorene (174753-91-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; caesium carbonate; In water; toluene; at 90 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201700877

Reference yield:

tetrakis(triphenylphosphine)palladium (0) + phenylboronic acid (98-80-6) → 9,9-dimethyl-7-phenyl-9H-fluorene (174753-91-4)

Guidance literature:

With sodium carbonate; In 1,2-dimethoxyethane; water; ethyl acetate;

upstream raw materials:

2-bromo-9,9-dimethyl-9H-fluorene

phenylboronic acid

phenylmagnesium bromide

9,9-dimethyl-9H-fluoren-2-ylamine

Downstream raw materials:

2-(4-bromophenyl)-9,9-dimethyl-9H-fluorene

2-bromo-7-phenyl-9,9-dimethyl-9H-fluorene

C₆₃H₄₆

C₆₃H₄₆