Technology Process of Phenol, 3-[(1S,2S)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-,
hydrochloride
There total 4 articles about Phenol, 3-[(1S,2S)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-,
hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N,N-dimethyl-2-methyl-3-(3-hydroxyphenyl)valeramide;
With
aluminum (III) chloride; lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Reflux;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
With
chloro-trimethyl-silane;
In
acetone;
- Guidance literature:
-
(2S,3R)-1-dimethylamino-3-(3-hydroxyphenyl)-2-methylpentan-3-ol tartrate;
With
palladium on carbon; hydrogen; trifluoroacetic anhydride;
In
2-methyltetrahydrofuran; water;
at 44.84 - 49.84 ℃;
for 5h;
under 3677.86 - 5149.01 Torr;
Autoclave;
With
hydrogenchloride;
In
isopropyl alcohol;
at 19.84 - 24.84 ℃;
for 1h;
pH=1 - 2;
DOI:10.1107/S0108270111001727
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ammonia / water
2.1: palladium on carbon; hydrogen; trifluoroacetic anhydride / 2-methyltetrahydrofuran; water / 5 h / 44.84 - 49.84 °C / 3677.86 - 5149.01 Torr / Autoclave
2.2: 1 h / 19.84 - 24.84 °C / pH 1 - 2
With
palladium on carbon; ammonia; hydrogen; trifluoroacetic anhydride;
In
2-methyltetrahydrofuran; water;
DOI:10.1107/S0108270111001727
