2,4-Di-tert-butyl-6-methoxyphenylboronic acid

Base Information

• Chemical Name: 2,4-Di-tert-butyl-6-methoxyphenylboronic acid
• CAS No.: 175602-46-7
• Molecular Formula: C15H25BO3
• Molecular Weight: 264.173
• DSSTox Substance ID: DTXSID90448154
• Nikkaji Number: J708.626A
• Wikidata: Q82267111

Synonyms:175602-46-7;(2,4-Di-tert-butyl-6-methoxyphenyl)boronic acid;2,4-Di-tert-butyl-6-methoxyphenylboronic acid;starbld0019225;SCHEMBL10296004;DTXSID90448154;Boronic acid, [2,4-bis(1,1-dimethylethyl)-6-methoxyphenyl]-

Chemical Property of 2,4-Di-tert-butyl-6-methoxyphenylboronic acid

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 264.1896748
• Heavy Atom Count: 19
• Complexity: 291

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C=C(C=C1OC)C(C)(C)C)C(C)(C)C)(O)O

Technology Process of 2,4-Di-tert-butyl-6-methoxyphenylboronic acid

There total 2 articles about 2,4-Di-tert-butyl-6-methoxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-bromo-1,5-di-tert-butyl-3-methoxybenzene (153872-77-6) → 2,4-di-tert-butyl-6-methoxyphenylboronic acid (175602-46-7)

Guidance literature:

2-bromo-1,5-di-tert-butyl-3-methoxybenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With Trimethyl borate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With water; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/anie.200803193

Reference yield:

C17H29BO3 → 2,4-di-tert-butyl-6-methoxyphenylboronic acid (175602-46-7)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h;

DOI:10.1021/jo8014819

Reference yield: 91.0%

quinolin-6-yl 4-methylbenzene-1-sulfonate (426265-40-9) + 2,4-di-tert-butyl-6-methoxyphenylboronic acid (175602-46-7) → 6-(2,4-di-tert-butyl-6-methoxyphenyl)quinoline (1067883-77-5)

Guidance literature:

With potassium phosphate; palladium diacetate; In tert-butyl alcohol; at 110 ℃; for 3h;

DOI:10.1021/jo8014819

upstream raw materials:

2-bromo-1,5-di-tert-butyl-3-methoxybenzene

Downstream raw materials:

2-(2,4-Di-tert-butyl-6-methoxy-phenyl)-3-methyl-pyridine

1,3-di-tert-butyl-5-methoxybenzene

3,5-di-tert-butyl-2-(6'-bromo-2'-pyridyl)anisole

6-(2',4'-di-tert-butyl-6'-methoxyphenyl)pyridine-2-carboxyaldehyde

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