1-(2-Amino-5-hydroxyphenyl)ethanone

Base Information

• Chemical Name: 1-(2-Amino-5-hydroxyphenyl)ethanone
• CAS No.: 30954-71-3
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.165
• Hs Code.: 2922509090
• European Community (EC) Number: 827-060-8
• DSSTox Substance ID: DTXSID40184934
• Nikkaji Number: J88.689K
• Wikidata: Q72437671
• Mol file: 30954-71-3.mol

Synonyms:2-amino-5-hydroxyacetophenone

Chemical Property of 1-(2-Amino-5-hydroxyphenyl)ethanone

Chemical Property:

• Vapor Pressure: 1.23E-05mmHg at 25°C
• Melting Point: 157-161℃
• Refractive Index: 1.613
• Boiling Point: 358.5 °C at 760 mmHg
• PKA: 9.40±0.18(Predicted)
• Flash Point: 170.6 °C
• PSA: 63.32000
• Density: 1.242 g/cm³
• LogP: 1.75820
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Amino-5-hydroxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(C=CC(=C1)O)N

Technology Process of 1-(2-Amino-5-hydroxyphenyl)ethanone

There total 13 articles about 1-(2-Amino-5-hydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-(5-hydroxy-2-nitrophenyl)ethan-1-one (30879-49-3) → 2′-amino-5′-hydroxyacetophenone (30954-71-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethanol; at 30 ℃; for 2h; under 2250.23 Torr;

DOI:10.1002/cbdv.201000307

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → 2′-amino-5′-hydroxyacetophenone (30954-71-3) + 4-amino-phenol (123-30-8)

Guidance literature:

In water; at 20 ℃; UV-irradiation;

DOI:10.1039/c2pp25341k

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → 2′-amino-5′-hydroxyacetophenone (30954-71-3) + 3-Hydroxyacetaminophen (37519-14-5) + (2E,4Z)-2-acetyl-3-amino-6-oxohexa-2,4-dienoic acid + 4-amino-phenol (123-30-8)

Guidance literature:

In water; at 24.84 ℃; for 0.766667h; under 760.051 Torr; pH=6.5; Photolysis;

DOI:10.1016/j.jphotochem.2013.10.006

upstream raw materials:

1-(2-azido-phenyl)-ethanone

1-(5-hydroxy-2-nitrophenyl)ethan-1-one

3-methylbenzo[c]isoxazole

3-Hydroxyacetophenone