Benzenebutanoic acid, 3-bromo-, ethyl ester

Base Information

• Chemical Name: Benzenebutanoic acid, 3-bromo-, ethyl ester
• CAS No.: 176088-58-7
• Molecular Formula: C12H15BrO2
• Molecular Weight: 271.154
• Mol file: 176088-58-7.mol

Synonyms:BENZENEBUTANOIC ACID, 3-BROMO-, ETHYL ESTER;

Chemical Property of Benzenebutanoic acid, 3-bromo-, ethyl ester

Chemical Property:

• PSA: 26.30000
• LogP: 3.33490

Purity/Quality:

BENZENEBUTANOICACID,3-BROMO-,ETHYLESTER 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanoic acid, 3-bromo-, ethyl ester

There total 13 articles about Benzenebutanoic acid, 3-bromo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 4-(3-bromophenyl)-2-butenoate (937250-45-8) → ethyl 4-(3-bromophenyl)butanoate (176088-58-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 24h; under 760.051 Torr;

Reference yield: 88.0%

diazoacetic acid ethyl ester (623-73-4) + 3-bromostyrene (2039-86-3,25584-47-8) → ethyl 4-(3-bromophenyl)butanoate (176088-58-7)

Guidance literature:

With p-cresol; tris(bipyridine)ruthenium(II) dichloride hexahydrate; In dichloromethane; at 25 ℃; for 12h; Irradiation;

Reference yield: 77.5%

ethyl 4-(3-aminophenyl)butanoate → ethyl 4-(3-bromophenyl)butanoate (176088-58-7)

Guidance literature:

ethyl 4-(3-aminophenyl)butanoate; With hydrogen bromide; sodium nitrite; In water;

With hydrogen bromide; copper(I) bromide; In water; acetone; for 1h;

DOI:10.3987/COM-05-S(T)78

upstream raw materials:

ethyl 2-(3-bromophenyl)acetate

ethyl (triphenylphosphoranylidene)acetate

2-(3-bromophenyl)ethan-1-ol

1-bromo-3-(2'-iodoethyl)benzene

Downstream raw materials:

5-(3-bromophenyl)-2-methyl-2-pentanol

Refernces

• 1、 -. "Preparation method of substituted butyrate derivatives". Paragraph 0105-0108. . Retrieved 2020/07/15.
• 2、 -. "RETINOID COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATES THEREOF AND APPLICATION THEREOF". Paragraph 0132; 0133. . Retrieved 2019/01/29.