Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-

Base Information

Chemical Name:Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-
CAS No.:74536-61-1
Molecular Formula:C₁₈H₂₀F₂O₂
Molecular Weight:306.352
Hs Code.:
DSSTox Substance ID:DTXSID10225540
Wikidata:Q83104540

Synonyms:BRN 2477269;Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-;meso-3,4-Bis(3-fluoro-4-hydroxyphenyl)hexane;4,4'-(1,2-Diethylethylene)bis(2-fluorophenol);74536-61-1;DTXSID10225540;C18H20F2O2;LS-104373

Suppliers and Price of Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-

Chemical Property:

Vapor Pressure:3.37E-06mmHg at 25°C
Boiling Point:376.3°Cat760mmHg
Flash Point:181.4°C
Density:1.197g/cm³
XLogP3:5.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:306.14313620
Heavy Atom Count:22
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C1=CC(=C(C=C1)O)F)C(CC)C2=CC(=C(C=C2)O)F
Isomeric SMILES:CC[C@H](C1=CC(=C(C=C1)O)F)[C@@H](CC)C2=CC(=C(C=C2)O)F

Technology Process of Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro-

There total 10 articles about Phenol, 4,4'-(1,2-diethylethylene)bis(2-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2249-64-1
meso-3,3'-difluorohexestrol dimethyl ether

: 970-03-6,74536-61-1
meso-3,4-bis(3-fluoro-4-hydroxyphenyl)hexane

Guidance literature:: With boron tribromide; In dichloromethane; 1.) -60 deg C, 0.5 h, 2.) RT, 4 h;
DOI:10.1021/jm00362a010

Reference yield: 75.0%

: 74536-60-0
meso-3,3'difluorohexestrol 4,4'-dimethyl ether

: 74536-61-1
3,3'-Difluorohexestrol

Guidance literature:: With boron tribromide; In dichloromethane; at 4 ℃; for 12h;
DOI:10.1021/jm00183a007

Reference yield:

: 84-16-2,26614-21-1
hexestrol

: 74536-61-1
3,3'-Difluorohexestrol

Guidance literature:: Multi-step reaction with 6 steps

1: 14 percent / acetic anhydride, Cu(NO₃)2*3H₂O / acetic acid; tetrahydrofuran / 0.17 h

2: K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

3: 97 percent / H₂ / Pd/C (5percent) / tetrahydrofuran / 12 h / 760 Torr

4: 1.) HClaq conc., NaNO₂, 2.) HBF₄

5: 53 percent / decane / 0.5 h / 160 °C

6: 75 percent / BBr₃ / CH₂Cl₂ / 12 h / 4 °C

With hydrogenchloride; tetrafluoroboric acid; hydrogen; acetic anhydride; boron tribromide; potassium carbonate; copper(II) nitrate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; decane; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00183a007