Technology Process of meso-3,3'difluorohexestrol 4,4'-dimethyl ether
There total 5 articles about meso-3,3'difluorohexestrol 4,4'-dimethyl ether which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 14 percent / acetic anhydride, Cu(NO3)2*3H2O / acetic acid; tetrahydrofuran / 0.17 h
2: K2CO3 / dimethylformamide / 48 h / Ambient temperature
3: 97 percent / H2 / Pd/C (5percent) / tetrahydrofuran / 12 h / 760 Torr
4: 1.) HClaq conc., NaNO2, 2.) HBF4
5: 53 percent / decane / 0.5 h / 160 °C
With
hydrogenchloride; tetrafluoroboric acid; hydrogen; acetic anhydride; potassium carbonate; copper(II) nitrate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; decane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00183a007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: K2CO3 / dimethylformamide / 48 h / Ambient temperature
2: 97 percent / H2 / Pd/C (5percent) / tetrahydrofuran / 12 h / 760 Torr
3: 1.) HClaq conc., NaNO2, 2.) HBF4
4: 53 percent / decane / 0.5 h / 160 °C
With
hydrogenchloride; tetrafluoroboric acid; hydrogen; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; decane; N,N-dimethyl-formamide;
DOI:10.1021/jm00183a007
