3H-Pyrrol-3-one, 2-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-4-[(1R,2R)-2,3-dihydro-2- hydroxy-1H-inden-1-yl]-1,2-dihydro-2-(phenylmethyl)-, (2S)-

Base Information

• Chemical Name: 3H-Pyrrol-3-one, 2-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-4-[(1R,2R)-2,3-dihydro-2- hydroxy-1H-inden-1-yl]-1,2-dihydro-2-(phenylmethyl)-, (2S)-
• CAS No.: 177845-03-3
• Molecular Formula: C30H32N2O3
• Molecular Weight: 468.596
• Mol file: 177845-03-3.mol

Synonyms:

Chemical Property of 3H-Pyrrol-3-one, 2-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-4-[(1R,2R)-2,3-dihydro-2- hydroxy-1H-inden-1-yl]-1,2-dihydro-2-(phenylmethyl)-, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3H-Pyrrol-3-one, 2-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-4-[(1R,2R)-2,3-dihydro-2- hydroxy-1H-inden-1-yl]-1,2-dihydro-2-(phenylmethyl)-, (2S)-

There total 12 articles about 3H-Pyrrol-3-one, 2-[(2S,3S)-3-amino-2-hydroxy-4-phenylbutyl]-4-[(1R,2R)-2,3-dihydro-2- hydroxy-1H-inden-1-yl]-1,2-dihydro-2-(phenylmethyl)-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(4S,5S)-4-Benzyl-5-{(S)-2-benzyl-4-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-indan-1-yl]-3-oxo-2,3-dihydro-1H-pyrrol-2-ylmethyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (177845-02-2) → (S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-2-benzyl-4-((1R,2R)-2-hydroxy-indan-1-yl)-1,2-dihydro-pyrrol-3-one (177845-03-3)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jm970195u

Reference yield:

3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-2-one (178032-91-2) → (S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-2-benzyl-4-((1R,2R)-2-hydroxy-indan-1-yl)-1,2-dihydro-pyrrol-3-one (177845-03-3)

Guidance literature:

Multi-step reaction with 6 steps

1: trimethyl aluminum / benzene / 16 h

2: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

3: 92 percent / DIBAL / tetrahydrofuran; hexane / 0.75 h / -78 °C

4: CHCl₃

5: 123.5 mg / KHMDS / tetrahydrofuran; toluene / 0.17 h / 20 °C

6: 91 percent / HCl / methanol / 4.5 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; trimethylaluminum; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; toluene; benzene;

DOI:10.1021/jm0204587

Reference yield:

[(1S,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-indan-1-yl]-acetaldehyde (177845-01-1) → (S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-2-benzyl-4-((1R,2R)-2-hydroxy-indan-1-yl)-1,2-dihydro-pyrrol-3-one (177845-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1: CHCl₃

2: 123.5 mg / KHMDS / tetrahydrofuran; toluene / 0.17 h / 20 °C

3: 91 percent / HCl / methanol / 4.5 h / 20 °C

With hydrogenchloride; potassium hexamethylsilazane; In tetrahydrofuran; methanol; chloroform; toluene;

DOI:10.1021/jm0204587

upstream raw materials:

(4S,5S)-4-Benzyl-5-{(S)-2-benzyl-4-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-indan-1-yl]-3-oxo-2,3-dihydro-1H-pyrrol-2-ylmethyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-2-one

2,2a,7,7a-tetrahydro-cyclobuta[a]inden-1-one

(4S,5S)-5-((S)-2-Amino-2-methoxycarbonyl-3-phenyl-propyl)-4-benzyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester