N-benzyl-5-oxo-D-prolinamide

Base Information

Chemical Name:N-benzyl-5-oxo-D-prolinamide
CAS No.:178327-71-4
Molecular Formula:C12H14N2O2
Molecular Weight:218.255
Hs Code.:
DSSTox Substance ID:DTXSID40427535
Wikidata:Q82240189
Mol file:178327-71-4.mol

Synonyms:N-benzyl-5-oxo-D-prolinamide;AC1OEIM8;178327-71-4;SCHEMBL1162611;DTXSID40427535;MDCKMKIRZIXFCH-SNVBAGLBSA-N

Suppliers and Price of N-benzyl-5-oxo-D-prolinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-benzyl-5-oxo-D-prolinamide

Chemical Property:

XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:218.105527694
Heavy Atom Count:16
Complexity:272

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC1C(=O)NCC2=CC=CC=C2
Isomeric SMILES:C1CC(=O)N[C@H]1C(=O)NCC2=CC=CC=C2

Technology Process of N-benzyl-5-oxo-D-prolinamide

There total 4 articles about N-benzyl-5-oxo-D-prolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 100-46-9
benzylamine

: 4042-36-8
D-pyrrolidone-5-carboxylic acid

: 178327-71-4
(R)-5-oxopyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm301674z

Reference yield:

: 4042-36-8
D-pyrrolidone-5-carboxylic acid

: 178327-71-4
(R)-5-oxopyrrolidine-2-carboxylic acid benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: PTSA / toluene / 16 h / Heating

2: acetonitrile / 0.17 h / 20 °C

With toluene-4-sulfonic acid; In toluene; acetonitrile;
DOI:10.1016/S0957-4166(02)00579-7