ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Base Information

• Chemical Name: ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
• CAS No.: 179064-00-7
• Molecular Formula: C18H16N2O4
• Molecular Weight: 324.336
• Hs Code.: 2933990090
• Mol file: 179064-00-7.mol

Synonyms:Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate;1-benzyl-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester;

Chemical Property of ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

Chemical Property:

• Boiling Point: 504.1±50.0 °C(Predicted)
• PKA: 4.50±1.00(Predicted)
• PSA: 81.42000
• Density: 1.375±0.06 g/cm3(Predicted)
• LogP: 2.32710

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

There total 2 articles about ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-benzyl-2H-pyrido<2,3-d><1.3>oxazine-2,4 1H-dione (97484-73-6) + diethyl malonate (105-53-3) → 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester (179064-00-7)

Guidance literature:

diethyl malonate; With sodium hydride; In ISOPROPYLAMIDE; at 20 ℃; for 0.5h;

N-benzyl-2H-pyrido<2,3-d><1.3>oxazine-2,4 1H-dione; In ISOPROPYLAMIDE; at 110 ℃; for 4h;

With hydrogenchloride; In ISOPROPYLAMIDE; water; at 0 ℃; pH=3;

Reference yield:

→ 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester (179064-00-7)

Guidance literature:

Reference yield: 98.0%

1-benzyl-4-hydroxy-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester (179064-00-7) → 1-benzyl-4-chloro-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester (847775-04-6)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 3h;

upstream raw materials:

N-benzyl-2H-pyrido<2,3-d><1.3>oxazine-2,4 1H-dione

diethyl malonate

Downstream raw materials:

1-benzyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2(1H)-one

N-[2-(aminosulfonyl)-4-bromophenyl]-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

N-cyclohexyl-1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide

1-benzyl-4-chloro-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester

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